Scientists from the
Dr. Christopher C. Broder, professor in the USU Department of Microbiology and Immunology, and Dr. Katharine Bossart, a former graduate student in that department and now postdoctoral fellow at the AAHL, along with their Australian colleagues, explained their vaccine discovery in the Sept. 27, 2006 online edition of the Journal of Virology.
Nipah virus and Hendra virus are recently emerged and closely related viral
pathogens and both agents are considered to be potential biological terror agents.
Nipah virus killed more than 100 people and a million pigs in
The new vaccine is composed of a component of the virus particle known as the
G glycoprotein, and its use has demonstrated complete protection from infection by Nipah virus in a feline model. Because these viruses are so similar, immunization with the component from either Hendra or Nipah protected against challenge from both, indicating that a single vaccine may be effective against both.
Although members of this group of viruses have only caused a handful of focal outbreaks, the biologic property of these viruses to infect a wide range of hosts and to produce a disease causing significant mortality in humans and the recognition of their reservoirs in nature has made this emerging viral infection a public health concern.
Hendra virus reemerged in
There are currently no approved vaccines available for Hendra virus or Nipah virus and no anti-viral drugs available to treat these types of viruses in general. The development and testing of this subunit vaccine was supported by the Middle Atlantic Regional Centers of Excellence and the National Institutes of Health.
Established by the U.S. Congress in 1972, the
Source: the Uniformed