A Creighton University physicist was part of an international team which explored the process involved in how cells combat bacterial infection and discovered new capabilities of cells fighting an infection. The team’s research was published Nov. 24, 2014, in the journal Proceedings of the National Academy of Sciences of the United States of America.
Andrew E. Ekpenyong, PhD, is the co-first author on the collaboratively published paper, titled “Actin polymerization as a novel innate immune effector mechanism to control salmonella infection.” The paper explains how cells contain infectious diseases and opens up a new conversation about options for disease management and treatment. Ekpenyong worked with a team of researchers based out of the University of Cambridge, in the United Kingdom, and the Technical University of Dresden, in Germany.
The study has shown, for the first time, that while bacterial infections evolve, the body’s cells are also evolving to fend off infection. Looking at salmonella’s behaviors both in laboratory work and in mice, Ekpenyong and his colleagues determined the mice’s cells were using physical properties to slow down the infection. It had previously been thought that once salmonella penetrated a cell’s defenses, it took up residence in a vacuole in the cell until the cell’s death. This latest observation, Ekpenyong said, shows the cell actually puts up stiffer resistance, slowing the infection and keeping it from spreading so quickly to more cells. The new research hinges on the group’s isolation of a particular molecule, complex protein known as NLRC4.
“What we saw were the body’s cells changing, stiffening to fight off the infection,” says Ekpenyong, who is also a product of Creighton’s graduate school. “It’s very exciting because this was unknown before. The potential of this is that we can think of antibodies that can enhance this molecule and further slow the infection.”
Ekpenyong and the other researchers on this project were at work for more than four years on this study. With infectious diseases responsible for one-third of all deaths in the world each year, he’s hopeful this new discovery can lead to more treatment strategies.
“It is opening up new possibilities,” Ekpenyong says. “This might help in the fight with a broad range of bacterial infections. At the very least, it has helped us better understand how pathogens interact with cells.”
Source: Creighton University