Monitoring the Microbiome in Leukemia Patients Could Reduce Infections During Chemotherapy

Researchers report that a patient's microbial diversity, even before they start cancer treatment, can be linked to risk of infection during induction chemotherapy. This research was presented at ASM's Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC/ICC).

Jessica Galloway-Peña, PhD, a fellow in the Department of Infectious Diseases, Infection Control and Employee Health at the University of Texas MD Anderson Cancer Center, and her colleagues show that disruption of the microbiome by illness or the administration of therapeutics can often lead to detrimental effects in a patient, particularly in immunocompromised cancer patients with an increased probability for infectious complications.

The microbiome is all of the microscopic organisms present in association with the human body. Many microorganisms live in harmony with their human hosts, as well as living in equilibrium with other microorganisms in order to provide functions essential for human health and survival.

"We found the baseline microbial diversities from stool samples were significantly lower in patients that developed infections during chemotherapy compared to those that did not," says Galloway-Peña. "Additionally, there is a significant decrease in oral and intestinal microbial diversity over the course of chemotherapy," she added.

On top of decreases in microbial diversity, it was also shown that over the course of chemotherapy there was an increase in the presence of specific groups of microorganisms known to cause infection. In those cases, patients' intestinal microbiomes would often be dominated by those classes of infectious agents. Patients that were able to maintain a healthy microbiome remained infection free in the 90 days post chemotherapy.

Furthermore, it was found that of the most common treatment antibiotics, carbapenems, most significantly decreased microbial diversity.

"This study shows that in the future doctors could use microbiome sampling in order to predict the chance of infectious complications during chemotherapy, and that monitoring of a patient's microbiome during induction chemotherapy could also predict their risk for microbial related illness during subsequent treatments," says Galloway-Peña. Additionally, these patients receive vast amounts of antibiotics (on average, approximately five different antibiotics were received per patient in this study) because of the high possibility of infections. Monitoring of the microbiome could potentially mitigate the over use of antimicrobials by stratifying patients into low and high risk groups as well as be used to predict on-coming infections. This could, in turn, improve the antibiotic resistance problem currently plaguing our medical field.

This work was performed through a joint collaboration between the Infectious Diseases Department at MD Anderson and the Alkek Center for Metagenomics and Microbiome Research at Baylor College of Medicine in Houston, Texas. This work was largely envisioned by Samuel A. Shelburne MD, PhD, Dimitrios Kontoyiannis MD, ScD, and Joseph Petresino PhD, and funded by an institutional Knowledge Gap Grant from MDACC. The research and analyses were primarily performed by Jessica Galloway-Peña PhD, Daniel Smith PhD, and Nadim Ajami PhD. This work was presented by Jessica Galloway-Peña PhD at ASM's Interscience Conference of Antimicrobial Agents and Chemotherapy in San Diego on Sept. 20, 2015.

Source: American Society for Microbiology



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