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Microbial biofilms develop when microorganisms adhere to a surface such as a surgical instrument, an indwelling catheter or other medical device and produce extracellular polymers that facilitate adhesion and provide a structural matrix. Biofilms on indwelling medical devices may be composed of Gram-positive or Gram-negative bacteria or yeasts. Biofilms are frequently implicated in device-related infections.

  • Protein Disrupts Infectious Biofilms
    Many infectious pathogens are difficult to treat because they develop into biofilms, layers of metabolically active but slowly growing bacteria embedded in a protective layer of slime, which are inherently more resistant to antibiotics. Now, a group of researchers at ...More
    Yesterday Posted in News
  • Molecular Chameleons Reveal Bacterial Biofilm
    Bacterial infections are especially resilient to treatment when individual bacteria group together and form what is known as a biofilm. Biofilm formation can now be studied as it happens using chemicals that fluoresce at different wavelengths as their conformation changes. ...More
    3 weeks ago Posted in News
  • Creating a Slippery Slope on the Surface of Medical Implants
    Implanted medical devices such as left ventricular-assist devices for patients with heart failure or other support systems for patients with respiratory, liver or other end organ disease save lives every day. However, bacteria that form infectious biofilms on those devices, ...More
    November 1, 2016 Posted in News
  • Understanding Bacteria's Slimy Fortresses
    Princeton researchers have for the first time revealed the mechanics of how bacteria build up slimy masses, called biofilms, cell by cell. When encased in biofilms in the human body, bacteria are a thousand times less susceptible to antibiotics, making certain infections, ...More
    October 21, 2016 Posted in News
  • Plant-Made Antimicrobial Peptide Targets Dental Plaque Biofilms
    Protein drugs, which derive from biological sources, represent some of the most important and effective biopharmaceuticals on the market. Some, like insulin, have been used for decades, while many more based on cloned genes are coming to market and are valued for their ...More
    October 5, 2016 Posted in News
  • Genes Found in H. pylori That Influence Biofilm Formation
    Most bacteria cannot survive in the acidic environment of the human stomach, but Helicobacter pylori, a major cause of ulcers, thrives under such circumstances. Now research has shown that one of that bacterium's regulatory proteins that helps it adapt to these stressful ...More
    July 18, 2016 Posted in News
  • Biofilm Formation May Complicate Some Necrotizing Soft Tissue Infections
    Group A streptococcus (GAS) can cause a life-threatening necrotizing fasciitis, which spreads rapidly and destroys soft tissue. Treatment of these GAS necrotizing soft tissue infections (NSTI) typically requires intensive care along with surgical intervention and often ...More
    July 7, 2016 Posted in News
  • Researchers Develop Effective Strategy for Disrupting Bacterial Biofilms
    Biofilms are communities of bacteria that adhere to a surface and are nearly impossible to eradicate when they are pathogenic, or disease-causing. Fortunately, a discovery from the laboratories of Lauren Bakaletz, PhD, and Steven Goodman, PhD, in The Research Institute at ...More
    June 30, 2016 Posted in News
  • Pitt-Developed Drug Works Against Bacterial Biofilms and Respiratory Virus
    A potential drug therapy developed at the University of Pittsburgh Center for Vaccine Research (CVR) has proven effective against tough bacterial biofilms and a deadly respiratory virus simultaneously. The drug outperforms traditional therapies in the laboratory setting. ...More
    May 9, 2016 Posted in News
  • Novel Anti-Biofilm Nano Coating Developed by Ben-Gurion Researchers
    Researchers at Ben-Gurion University of the Negev (BGU) have developed an innovative anti-biofilm coating, which has significant anti-adhesive potential for a variety of medical and industrial applications. According to the research published in Advanced Materials ...More
    April 25, 2016 Posted in News
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