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Clostridium Difficile

Clostridium difficile (C. diff) is a spore-forming, Gram-positive anaerobic bacillus that produces two exotoxins: toxin A and toxin B. Clostridium difficile is shed in feces. Any surface, device, or material that becomes contaminated with feces may serve as a reservoir for the Clostridium difficile spores. Clostridium difficile spores are transferred to patients mainly via the hands of healthcare personnel who have touched a contaminated surface or item. Clostridium difficile infection be prevented in hospitals by the prudent use of antibiotics; the use of contact precautions for patients with known or suspected Clostridium difficile infection; preventing contamination of the hands via glove use and handwashing; and implement an environmental cleaning and disinfection strategy.

  • Fighting Hospital Pathogens With Sugar
    A vaccine against one of the most dangerous hospital germs may soon be available. Scientists from the Max Planck Institute of Colloids and Interfaces in Potsdam and the Freie Universität Berlin have developed a substance that elicits an immune response against the gut ...More
    May 12, 2016 Posted in News
  • Inhibitory Activity of Systemic Antibiotics Against Clostridium difficile
    Systemic antibiotics vary widely in in vitro activity against Clostridium difficile. Some agents with activity against C. difficile (e.g., piperacillin/tazobactam) inhibit establishment of colonization in mice. Kundrapu, et al. (2016) tested the hypothesis that ...More
    April 20, 2016 Posted in News
  • Northern New Jersey Hospitals Collaborate to Defeat Healthcare-Acquired Infections
    The Valley Hospital in Ridgewood, N.J., and Holy Name Medical Center in Teaneck, N.J., are collaborating to defeat Clostridium difficile. The two hospitals recently announced the formation of the Valley-Holy Name Joint Healthcare-Acquired Infections/Antibiotic Resistance ...More
    March 9, 2016 Posted in News
  • U-M Team Seeks to Outsmart C. difficile with New $9.2 Million Effort
    If you want to beat a fearsome enemy, you must first learn to think like them. If you do, you can predict their next move – and block it. This advice may work on the battlefield. But scientists also think it will work in humankind’s battle against one of the ...More
    March 9, 2016 Posted in News
  • Oral Capsule With Bacterial Spores May Be Effective Treatment for Recurrent C. difficile
    Results from a Phase 1b/2 trial suggest that an investigational microbiome-based, oral therapeutic drug is effective for the treatment of recurrent C. difficile infection. In a paper published online in the Journal of Infectious Diseases, a multi-institutional research team ...More
    February 9, 2016 Posted in News
  • C. diff Study Provides Insight Into Antibiotic Resistance and Risks for Infection
    Exposure to specific antibiotics is linked to the development of certain strains of antibiotic-resistant C. difficile, one of the fastest growing bacteria superbugs, according to a new study published by Stuart Johnson, MD, of Loyola University Health System (LUHS), Loyola ...More
    February 4, 2016 Posted in News
  • Mayo Clinic Uses Robots Against C. difficile
    Mayo Clinic has added robots in its fight against Clostridium difficile (C. diff) bacteria. In the U.S., C. diff is one of the most common infections patients can get while receiving care at a healthcare facility. C. diff can cause a variety of symptoms, including ...More
    January 20, 2016 Posted in News
  • Frozen Fecal Material Just as Good as Fresh for C. diff Patients
    Frozen fecal transplantation is effective at providing relief to Clostridium difficile (C. diff) patients, according to a new study co-authored by University of Guelph researchers. The study found that frozen fecal microbiota transplantation (FMT) is just as effective as ...More
    January 14, 2016 Posted in News
  • Developing Probiotic Mixes to Treat Intestinal Infections
    Antibiotics that fight infection can adversely affect the digestive tract and give destructive bacteria a chance to flourish, said assistant professor of veterinary and biomedical sciences Joy Scaria of South Dakota State University. His research seeks to identify probiotic ...More
    January 11, 2016 Posted in News
  • Researchers Closer to a Better Treatment for Clostridium difficile
    Researchers at Vanderbilt University Medical Center have obtained the crystal structure of a toxin from the bacterium Clostridium difficile (C. diff) -- the leading cause of hospital-acquired diarrhea in the United States. Reporting in this week's Nature Microbiology, they ...More
    January 11, 2016 Posted in News