Macrophages

  • Same Conditions, Different Outcome in Fungal Infection
    Cryptococcus neoformans is a life-threatening human fungal pathogen that is responsible for an estimated 1 million cases of meningitis each year, primarily in HIV-infected and other immunocompromised patients. Interaction with immune cells called macrophages is a key step ...More
    September 1, 2011
    Posted in News, Infections & Pathogens
  • How Q Fever Invades and Replicates Inside Killer Immune Cells
    As part of its life cycle Coxiella burnetii, the bacterial pathogen responsible for Q fever, replicates inside a membrane-bound compartment or "parasitophorous vacuole" (PV) within immune cells. The organism manipulates macrophages to create the PV as well as optimal ...More
    September 1, 2011
    Posted in News, Infections & Pathogens
  • Virus, Parasite May Combine to Increase Harm to Humans
    A parasite and a virus may be teaming up in a way that increases the parasite’s ability to harm humans, scientists at the University of Lausanne in Switzerland and Washington University School of Medicine in St. Louis report this week in Science. When the parasite ...More
    February 11, 2011
    Posted in News
  • Unexpected Find Opens Up New Front in Effort to Stop HIV
    HIV adapts in a surprising way to survive and thrive in its hiding spot within the human immune system, scientists have learned. While the finding helps explain why HIV remains such a formidable foe after three decades of research – more than 30 million people worldwide are ...More
    January 24, 2011
    Posted in News
  • Researchers Discover Important Mechanism in Fighting Infection
    Richard Lamb and his post doctoral fellow Virginie Mieulet, in the Faculty of Medicine & Dentistry at the University of Alberta, may be able to explain why proper nutrition is so vital in fighting infection. They have discovered an amino acid, called arginine, is ...More
    August 30, 2010
    Posted in News
  • Macrophages: The Defense Cells That Regulate Immunity and Help Heal Wounds
    The term "macrophage" conjures images of a hungry white blood cell gobbling invading bacteria. However, macrophages do much more than that: Not only do they act as antimicrobial warriors, they also play critical roles in immune regulation and wound-healing. They can respond ...More
    August 26, 2010
    Posted in News
  • Old Drug Holds Promise Against Opportunistic Lung Pathogen
    A drug to treat inflammation plays a surprising role reducing the level of infection caused by an opportunistic bug that is deadly for AIDS and cancer patients and others with weakened immune systems. The drug, sulfasalazine, spurs the body to get rid of the fungal evaders ...More
    August 20, 2010
    Posted in News
  • Researchers Discover Cause of Immune System Avoidance of Certain Pathogens
    A special set of sugars found on some disease-causing pathogens helps those pathogens fight the body's natural defenses as well as vaccines, say two Iowa State University researchers. This discovery may be a first step in understanding a disease family that includes ...More
    August 18, 2010
    Posted in News
  • Scientists Discover How Protein Trips Up Bacteria
    If bad bacteria lurk in your system, chances are they will bump into the immune system’s protective cells whose job is gobbling germs. The catch is that these do-gooders, known as macrophages, ingest and destroy only those infectious invaders that they can securely ...More
    February 17, 2010
    Posted in News
  • Protein Found to be Key in Protecting the Gut from Infection
    A signaling protein that is key in orchestrating the body’s overall immune response has an important localized role in fighting bacterial infection and inflammation in the intestinal tract, according to a study by UC San Diego School of Medicine investigators, ...More
    February 17, 2010
    Posted in News
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