Animal Trial to Test Promising Vaccine for H1N1

Animal Trial to Test Promising Vaccine for H1N1

An H1N1 vaccine developed at the University of Nebraska Medical Center will enter a definitive round of testing this month, and researchers hope to establish its ability to ward off the virus. Made possible by a licensing deal brokered through UNMC's technology transfer office, UNeMed Corporation, the study will evaluate the vaccine on 30 to 40 pigs. If tests yield results as expected, Prommune, Inc. could begin offering an H1N1 vaccine to hog farmers as early as the end of the year, although full approval from the USDA would likely take another three or four years.

Sam Sanderson, PhD, is working on an H1N1 vaccine that could be available to pig farmers by the end of this year. Photo courtesy of University of Nebraska Medical Center

An H1N1 vaccine developed at the University of Nebraska Medical Center will enter a definitive round of testing this month, and researchers hope to establish its ability to ward off the virus. Made possible by a licensing deal brokered through UNMC's technology transfer office, UNeMed Corporation, the study will evaluate the vaccine on 30 to 40 pigs. If tests yield results as expected, Prommune, Inc. could begin offering an H1N1 vaccine to hog farmers as early as the end of the year, although full approval from the USDA would likely take another three or four years.

Ultimately, an H1N1 vaccine as potentially effective as Prommune's could dramatically diminish the virus as a global threat to the world's pig population and could even lead to more effective vaccines for similar diseases in birds and perhaps humans.

Prommune, Inc. was built around the research of Sam Sanderson, PhD, who founded the company in 2002. Sanderson is currently a research associate professor of pharmaceutical science in the UNMC College of Pharmacy.

Sanderson's technology essentially helps activate and direct the immune system into a more targeted and efficient attack against invading pathogens.

The technology, an immune stimulating peptide called EP67, is a "platform technology" that is so versatile it can be tweaked and modified to work against a number of ailments and in a wide variety of animals.

In addition to the H1N1 vaccine, EP67 could have applications against different varieties of the avian flu virus, antibiotic-resistant bacteria, and other infectious agents.

But long before Prommune can develop anything for human use, researchers still need to compile years of data – beginning with the planned trials in coming weeks, said Prommune's interim CEO Samer Al-Murrani, PhD.

Al-Murrani joined Prommune in March, after first meeting Sanderson at an animal health investment forum in Kansas City back in 2013.

Al-Murrani, who has a background in animal health and holds a doctorate in immunology and biochemistry, says a platform technology like EP67 would intrigue investors and strategic partners. Several recent initial public offerings in the animal health sector didn't compare well to Prommune's innovative technology, he said.

"I think Prommune today has more product and market potential than any of those companies," he says.

Al-Murrani is the chief executive officer of Babylon BioConsulting, a firm based in Cheyenne, Wyo., which specializes in bringing early-stage technologies to biomedical markets.

Since signing on with Prommune in March, Al-Murrani has helped Prommune build a corporate structure, negotiated the licensing deal with UNeMed and established a strategic alliance with a nationally renowned animal testing facility that helped open the door to the upcoming trial.

Source: University of Nebraska Medical Center (UNMC) 

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