New research conducted at the
To be effective, an HIV vaccine must induce the body to produce cross-reactive antibodies that can neutralize multiple strains. USU professors Capt. Gerald Quinnan, Jr., MD, USPHS, and Christopher Broder, PhD, and their colleagues at USU attempted to elicit these broad-range antibodies in an animal model by immunizing with a particular HIV-1 surface protein, designated R2 gp140, and an immune response-boosting component. The researchers tested antibodies generated by the immunizations to determine their effectiveness in neutralizing the infectivity of a variety of HIV-1 strains. Antibodies produced as a result of immunization neutralized all 48 strains of HIV-1 tested. The results are encouraging for vaccine development, because they showed that it is possible to elicit a broad-spectrum antibody response.
This research was supported by a grant from a number of collaborators including the National Institutes of Health/NIAID and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Source: Uniformed Services University of the Health Sciences (USU)