Pertussis Vaccine May Not Protect From Lesser-Known Species Bordetella parapertussis

A new study reports that an outbreak of Bordetella parapertussis occurred in 2014 in Southeastern Minnesota, in the months of October through December. This research is presented at ASM's 55th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC/ICC). One interesting finding is that all children involved in the outbreak were up to date with their pertussis vaccines.

"This leads us to believe that the vaccine is not protecting children from the lesser-known species, Bordetella parapertussis," says study author Vytas P. Karalius, MPH, MA, of the Mayo Medical School at Mayo Clinic.

Pertussis, commonly known as "whooping cough," has been on the rise in the United States and globally over the past 25 years. It is a disease that stems most notably from an infection with a bacterium called Bordetella pertussis. It is predominantly seen in children and starts similarly to a common cold. However, in most cases a serious cough develops with coughing spells that can be so bad as to cause vomiting and the hallmark gasping for air, which often causes a "whooping" sound in young children. The cough may be persistent, lasting for weeks, giving it the name "100 days cough." Due to vaccination of children against pertussis, the incidence of pertussis is lower in developed compared to developing countries. Despite the use of the vaccine, the incidence of pertussis is increasing.

Less commonly known is that the related species, Bordetella parapertussis, a "cousin" of B. pertussis, can cause a similar disease with the same symptoms.

"Our finding is consistent with other research previous to ours. The pertussis vaccine and its efficacy have been under recent scrutiny; it may be beneficial to consider targeting Bordetella parapertussis in the development of future vaccines," Karaliu says.

The cases presented with the symptoms of typical pertussis or whooping cough, indistinguishable from those expected with the better-known bacterium, Bordetella pertussis. Interestingly, over the same time period as the outbreak in Southeastern Minnesota, we observed a similar increase in the number of cases we diagnosed in our reference laboratory overall; our reference laboratory tests specimens from across the United States.

This research was presented as part of ASM's Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) held Sept. 17-21, 2015 in San Diego.

Source: American Society for Microbiology

Hide comments

Comments

  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Publish