Researchers at the Texas A&M Health Science Center Institute of Biosciences and Technology at
The virulence of CA-MRSA (community-associated methicillin-resistant Staphylococcus aureus) strains that produce the PVL (Panton Valentine leukocidin) toxin presents a nightmare scenario, said M. Gabriela Bowden, PhD, research assistant professor at HSC-IBT and co-senior author. If the community-acquired strain establishes itself in the hospital setting, it will be difficult to contain.
The most common cause of staph infections, S. aureus is a bacteria found on the skin or in the nose of about 25-30 percent of people. It also can be the culprit in minor skin infections like pimples and boils, as well as major diseases like meningitis, endocarditis, toxic shock syndrome and pneumonia.
In their study, Bowden and her colleagues at the
CA-MRSA causes serious skin and soft tissue infections in healthy persons who have not been recently hospitalized or undergone invasive medical procedures, while necrotizing pneumonia destroys healthy lung tissue and can be fatal within 72 hours. With the PVL toxin, the bacterium also attacks infection-fighting white blood cells (leukocytes).
In the 1940s, the high mortality rate from S. aureus was abated by penicillin, but the bacteria soon developed a resistance. Methicillin provided new treatment options for infections in the late 1950s, but as of the late 1990s, it has become resistant.
In December, the
Testing several bacterial strains, the HSC-IBT researchers learned PVL itself has an enhanced ability to disrupt cells in the body, and PVL-positive S. aureus has a greater capacity to attach to and colonize the lung, the latter resulting in necrotizing pneumonia.
Our research shows in vivo that PVL is sufficient to cause pneumonia, Bowden said. PVL-producing S. aureus overexpress other factors that enhance inflammation and bacterial attachment to the lung. These combined effects result in a vicious cycle of tissue destruction and inflammation, explaining the rapid onset and lethal outcome of this type of pneumonia.
Using these findings, the next step is additional studies to identify targets for potential development of therapies to treat S. aureus infections, including the PVL-positive strain.
The present study underscores the aggressiveness of these strains and the urgent need to develop new strategies to battle these infections, Bowden said.
Other Science Express study contributors from the Center for Extracellular Matrix Biology were Magnus Höök, PhD, director and professor; Eric Brown, PhD, assistant professor (now at The University of Texas School of Public Health at
Grants from the HSC, French Ministry of Research, National Institutes of Health, and Neva and Wesley West and Hamill Foundations supported this research.
The Texas A&M Health Science Center provides the state with health education, outreach and research. Its six components located in communities throughout
Source: Texas A&M Health Science Center Institute of Biosciences and Technology