PINE BROOK, N.J. -- Elusys Therapeutics, Inc., a biotechnology company developing targeted anti-infective antibodies to fight life-threatening infections, announces that it has entered into an exclusive collaborative research and license agreement with Pfizer Inc. to develop new therapeutics for select infectious diseases using Elusys' HP Antibody technology. The research collaboration will include ETI-211, an HP Antibody for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, in addition to research into other indications.
Under the terms of the agreement, Elusys and Pfizer will collaborate on determining the full product profile of ETI-211 and perform research on other indications of the HP Antibody technology. Elusys will receive an upfront equity investment, research and development funding plus near-term research milestones. Elusys has also granted Pfizer an option to acquire an exclusive worldwide license to products developed under the agreement, and upon exercise, the company will receive significant clinical and sales
milestones, as well as royalties on future sales of products resulting from the collaboration.
HP Antibodies represent a unique approach to the treatment of a variety of infectious diseases by enhancing the effectiveness of the body's natural defense mechanisms to remove and destroy life-threatening pathogens. An HP Antibody drug consists of a monoclonal antibody specific to an immune receptor (CR1) that is chemically linked to a second antibody that binds a particular pathogen. By targeting CR1, HP Antibodies enhance a natural clearance mechanism and direct the rapid removal of pathogens into liver macrophages, where they are destroyed and removed from the body.
Elizabeth Posillico, PhD, president and CEO of Elusys Therapeutics commented, "We are delighted that Pfizer has recognized the potential value of our HP Antibody technology as a novel approach for the treatment of life-threatening infections. Pfizer's impressive scientific team and expertise in infectious diseases provides Elusys with a strong partner to advance HP Antibody products into human clinical trials." Posillico added, "In parallel with the collaborative research on ETI-211, Elusys will continue to advance its other internal clinical development programs. These include Anthim, our Phase I therapeutic for anthrax infection and our HIV HP Antibody and CR1 Vaccine programs."
Source: Elusys Therapeutics Inc.