Based on an improved understanding of bacteriophages -- viruses that infect bacteria--scientists reporting in the Sept. 23 issue of the journal Nature believe they have discovered a potential new way to control drug-resistant bacteria, an increasingly worrisome public health problem.
The new research, funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that bacteriophages contain genes that allow them to quickly change their proteins to bind to different cell receptors. The researchers, who encountered this genetic property while working on an unrelated project, believe that this discovery could lead to the use of genetically engineered phages to treat bacterial infections that have become resistant to antibiotics.
"This serendipitous finding underscores the importance of basic research," says Anthony S. Fauci, MD, director of NIAID. "With our increased understanding of how bacteriophages work, we can potentially tailor these viruses to infect and destroy bacteria that have mutated and become drug-resistant."
"This powerful and innovative research opens up numerous possibilities for developing drugs and vaccines that can control resistant bacteria, which are a growing public health concern," says David L. Klein, PhD, who oversees bacterial respiratory disease research at NIAID. "The introduction of bacteriophages may also lead to a unique approach against biodefense-related pathogens."
The discovery was made by researchers at the
"Phage therapy has been practiced for nearly a hundred years in parts of the world, and even in the
Miller says that he and his team are continuing to study this genetic mechanism to learn more about its biochemical properties and to determine whether higher forms of life have similar classes of genes. He believes that, in time, they will be able to use the knowledge gleaned from this discovery to generate proteins in the laboratory that will bind to almost any molecule of interest.
Source: National Institute of Allergy and Infectious Diseases (NIAID)