HIV positive and HIV negative patients have comparable survival rates following liver transplant, according to new research presented today at EASL 2009, the annual meeting of the European Association for the Study of Liver in Copenhagen, Denmark.
The study results showed no difference in survival rates at 1 and 5 years between HIV negative and HIV positive patients (86.5 percent and 74 percent versus 87.1 percent and 78 percent, p=0.843), suggesting a good prognosis for HIV positive patients following liver transplant. However, the study confirmed that co-infection with hepatitis C virus (HCV) is a significant predictor of poorer survival rates in patients with HIV. Survival rates at 1 and 5 years were 73 percent and 53 percent in HIV positive patients with hepatitis C versus 87 percent and 69 percent (p=0.047) in HIV negative patients with hepatitis C.
Kosh Agarwal, of the
The researchers conducted a prospective analysis of the UK Transplant Database to determine the long-term outcomes in HIV patients undergoing liver transplant in the
HIV positive patients who tested negative for both hepatitis C and hepatitis B
HIV negative patients with hepatitis C
HIV positive patients with hepatitis C
The three patient groups were comparable according to the Model End Stage Liver Disease (MELD) scores, which is a numerical scale to score disease severity and improve organ allocation in transplantation. HIV positive patients were younger compared to HIV negative patients (mean 42.2 years versus 51.2, p=0.001) and HIV positive patients co-infected with hepatitis C were younger (mean 39.9 years versus 51.8; p=0.0001) than HIV negative patients with hepatitis C.