Scientists using an experimental treatment have slowed the progression of scrapie, a degenerative central nervous disease caused by prions, in laboratory mice and greatly extended the rodents’ lives, according to a new report in JCI Insight. The scientists used antisense oligonucleotides (ASOs), synthetic compounds that inhibit the formation of specific proteins.
Infectious Diseases & Conditions
Cellular 'Periscopes' in Blood Help Investigators 'See' Into Inaccessible Regions Where Immune Cells are Made
A rare, short-lived population of immune cells in the bloodstream may serve as 'periscopes' to monitor immune status via lymph nodes deep inside the body, according to researchers in the Perelman School of Medicine at the University of Pennsylvania. Their findings are published this month in the Journal of Clinical Investigation (JCI).
Researchers at the University of Illinois at Chicago have identified a molecular switch that causes immune cells called macrophages to clean up cellular debris caused by infections instead of contributing to inflammation and tissue injury.
Importance of Copy-Number Variants in the Development of Insecticide Resistance in Malaria Mosquitoes
Researchers from Liverpool School of Tropical Medicine (LSTM), working alongside colleagues from the Wellcome Sanger Institute, Cambridge and the Big Data Institute, University of Oxford, have used whole genome sequencing to understand copy-number variants (CNVs) in malaria mosquitoes and their role in insecticide resistance.
Scientists at Duke University have identified one kind of lung cell that can hustle to repair its damaged DNA and survive an attack of the influenza A virus while other kinds of cells around it die in droves.
Among HIV researchers, one seemingly indestructible HIV-like strain has earned the nickname "death star." That's due to the strain's reputation for killing off hopes for potential vaccines and immunotherapies that could prevent the disease.
A research team led by Tufts University engineers has developed a 3D printed pill that samples bacteria found in the gut -- known as the microbiome -- as it passes through the gastrointestinal tract (GI).
As Lyme disease increases, researchers have taken a significant step toward finding new ways to prevent its transmission. The experts, who include a pioneer in Lyme disease discovery, have sequenced the genome of the animal carrying the bacteria that causes the illness.
A team of scientists led by Texas Biomed's Assistant Professor Smita Kulkarni, PhD and Mary Carrington, PhD, at the Frederick National Laboratory for Cancer Research, published results of a study that pinpointed a long noncoding RNA molecule which influences a key receptor involved in HIV infection and progression of the disease.
Getting up close - and a little dirty - with farm animals just might help us fend off illness, say researchers who've further demonstrated the benefits of early exposure to a wide variety of environmental bacteria.