Researchers Crack Structure of Key Protein in Zika Virus
March 27th 2017Zika virus (ZIKV), which causes Zika virus disease, is spread to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. An infected pregnant woman can pass ZIKV to her fetus during pregnancy or around the time of birth. Sex is yet another way for infected persons to transmit ZIKV to others.
NUS Pharmacy Team Develops Calculator to Predict Risk of Early Hospital Readmission
March 27th 2017Patients who are discharged after a hospital stay will want to stay away from the hospital for as long as possible. However, in Singapore, approximately 15 percent of patients who have been discharged from hospitals will succumb to a readmission within 30 days, while globally, readmission rates within 30 days can be as high as 20 percent.
IP Stakeholders Series: Patient Safety and Quality
March 27th 2017The concept that infection prevention and patient safety is everyone's responsibility is nothing new, but some healthcare institutions may still be struggling to foster and nurture a culture of safety that permeates every department and every function. Taking the lead are directors and managers in patient safety and quality improvement, but infection preventionists (IPs) must also retain a prominent position as stakeholder in the process.
Product Evaluation & Purchasing: Temperature Management Technology in the OR
March 27th 2017Maintaining normothermia of the surgical patient is part of the prevention of surgical site infections, and a study by Steelman, et al. (2013) found that perioperative hypothermia was among the top patient safety issues identified by perioperative nurses. In this study, AORN members employed in ambulatory and hospital settings (N = 37,022) received an electronic survey; of the 3,137 returned surveys that contained complete information, 966 respondents (30.8 percent) identified prevention of hypothermia as a high priority. However, debate over the safety of forced-air warming systems continues, and clinicians should first and foremost consider all sides of the argument when making product evaluation and purchasing decisions. Alternatives to forced-air warming include direct-conduction fluid warming systems and systems that use conductive fabric technology. Conductive fabric systems do not require the use of a disposable blanket, which can help reduce waste and keep costs down.
Hydrophobic Proteins on Virus Surfaces Can Help Purify Vaccines
March 24th 2017Researchers hope to catch viruses for detection and vaccinations by understanding their sticky outer layers. The complex structures making the surface of a virus are small weaves of proteins that make a big impact on how a virus interacts with cells and its environment. A slight change in protein sequence makes this surface slightly water-repelling, or hydrophobic, causing it to stick to other hydrophobic surfaces. A new paper, published recently in Colloids and Surfaces B: Biointerfaces, details surface hydrophobicity in porcine parovirus (PPV).
Seven Months After Rio Olympics, Zika Continues to Plague Babies in Urban Slums
March 24th 2017Many international travelers to the 2016 Summer Olympics in Rio De Janeiro, Brazil, openly considered skipping the games to avoid the threat of Zika. Despite the fears, not a single case of Zika or its major neurological complication, microcephaly, was reported by foreign visitors. The near-paranoia -- and the diversion of scarce resources to protect a low-risk population -- could have been avoided by heeding the lessons of previous epidemics, argues a new study from public health researchers at UC Berkeley.
Mosquito Monitoring Has Limited Utility in Dengue Control, Study Finds
March 23rd 2017Cross-sectional surveys of mosquito abundance carried out in the subtropics and tropics are meant to give researchers an indication of the risk of a dengue virus outbreak in any given area. This type of entomological monitoring, however, is not a good proxy for dengue risk, researchers report this week in PLOS Neglected Tropical Diseases. Comparison of cross-sectional measures of mosquito density to longitudinal measures demonstrate the limitations of periodic entomological monitoring as households with exposure to Ae. aegypti may be misclassified as unexposed at any single survey visit.