Encouraging Decrease in Certain Antibiotic Resistance Levels of Gonococci Across Europe
September 2nd 2016In 2014, the susceptibility of gonococci to two of the recommended antibiotics for gonorrhea treatment has shown signs of improvement, according to results from the European Gonococcal Antimicrobial Surveillance Program (Euro-GASP). At the same time, a significant increase in resistance to another antibiotic agent that is part of the suggested dual therapy of gonorrhea was observed.
Strain Differences in Zika Infection Gene Patterns
September 1st 2016Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells. The results could provide insights into the Zika virus' recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.
Liberian Malaria Cases Declined Following Mass Drug Administration During Ebola Outbreak
September 1st 2016Mass drug administration may have reduced malarial incidence during the 2014 Ebola outbreak in Liberia, according to a study published August 31, 2016 in the open-access journal PLOS ONE by Anna Kuehne from Epicentre, France, and colleagues.
Sabotaging Bacteria Propellers to Stop Infections
August 31st 2016When looking at bacteria, you typically see also flagella: long hairs that protrudes from the bacteria's body. The key function of the flagella is movement - what scientists call "motility." The flagella give the bacteria the ability to swim in their environment by rotating like propellers. Bacteria can have a different number of flagella, and flagella are important because there is a clear correlation between motility and infection. Dr. Hideyuki Matsunami of the Trans-Membrane Trafficking Unit at the Okinawa Institute of Science and Technology Graduate University (OIST), together with a team of scientists, explored some aspects of the formation of flagella in research that may have implications for contrasting bacterial infections. They published their findings in Scientific Reports
Researchers Gain New Understanding of How Neutrophils Curb an Inflammatory Response
August 31st 2016As an arm of the innate immune system, white blood cells called neutrophils form the first line of defense against invading pathogens. Neutrophils spend most of their lives racing through the bloodstream, patrolling for bacteria or other foreign particles. Once they arrive at tissues besieged by infectious agents, they halt on a dime and then blast through the vessel wall to reach the inflammatory attack site. They do this by activating integrins, a class of adhesion receptors that can switch on in less than a second.