New Type of Compounds Prove Their Bacteria-Killing Ability in Animal Model


NEW YORK -- A new kind of bacteria-killing compounds, being called nubiotics, may prove to be potent antimicrobial agents in animal experiments, researchers are reporting in the August 2004 issue of the journal Antimicrobial Agents and Chemotherapy.


Nubiotics are based on nucleic acid and have shown strong activity against a variety of bacteria in the lab dish. They are believed to be completely different from conventional antibiotics, the researchers say, and could offer a new approach to treating burn and wound infections.


Dr. Roderic M. Dale of Oregon-based Oligos Etc., Inc. is the developer of these new compounds. Dale's team evaluated the efficacy of 12 different nubiotics in mice with burn wounds infected with a highly pathogenic strain of the bacterium, Pseudomonas aeruginosa. Four of the nubiotics proved "extremely efficacious," with 60 percent to 100 percent of treated mice surviving, compared with none of the untreated mice. These nubiotics were effective when given either by injection or when applied directly to the wound, the investigators found, resulting in nearly complete eradication of Pseudomonas from the spleen, liver, and blood.  In fact, they proved as effective as intravenous administration of ciprofloxacin, a broad-spectrum antibiotic.


Source: Antimicrobial Agents and Chemotherapy


Related Videos
Association for Professionals in Infection Control and Epidemiology  (Image credit: APIC)
Patient Safety: Infection Control Today's Trending Topic for March
Infection Control Today® (ICT®) talks with John Kimsey, vice president of processing optimization and customer success for Steris.
Picture at AORN’s International Surgical Conference & Expo 2024
An eye instrument holding an intraocular lens for cataract surgery. How to clean and sterilize it appropriately?   (Adobe Stock 417326809By Mohammed)
Photo of a model operating room. (Photo courtesy of Indigo-Clean and Kenall Manufacturing)
Washington, USA, US Treasury Department and Inspector General Office.    (Adobe Stock File 210945332 by Brian_Kinney)
A plasmid is a small circular DNA molecule found in bacteria and some other microscopic organisms. (Adobe Stock 522876298 by Love Employee)
Peter B. Graves, BSN, RN, CNOR, independent perioperative, consultant, speaker, and writer, Clinical Solution, LLC, Corinth, Texas; Maureen P. Spencer, M.Ed, BSN, RN, CIC, FAPIC, infection preventionist consultant, Infection Preventionist Consultants, Halifax, Massachusetts; Lena Camperlengo, DrPH, MPH, RN, Senior Director, Premier, Inc, Ocala, Florida.
Related Content