New Virus Discovered in the Blood Supply
More than 30 million blood components are transfused annually in the United States alone, and surveillance for infectious agents in the blood supply is key to ensuring the safety of this critical resource for medicine and public health. Scientists have discovered a new virus -- This new virus, human hepegivirus 1 (HHpgV-1), was found in serum samples from blood transfusion recipients, indicating its potential for transmission via blood and transfusion products.
In their study, Kapoora, et al. (2015) examined changes in the virome composition of blood transfusion recipients pre- and posttransfusion. Using this approach, they detected and genetically characterized a novel human virus, human hepegivirus 1 (HHpgV-1), that shares features with hepatitis C virus (HCV) and human pegivirus (HPgV; formerly called GB virus C or hepatitis G virus).
HCV and HPgV belong to the genera Hepacivirus and Pegivirus of the family Flaviviridae. HHpgV-1 was found in serum samples from two blood transfusion recipients and two hemophilia patients who had received plasma-derived clotting factor concentrates. In the former, the virus was detected only in the posttransfusion samples, indicating blood-borne transmission. Both hemophiliacs were persistently viremic over periods of at least 201 and 1,981 days. The 5′ untranslated region (UTR) of HHpgV-1 contained a type IV internal ribosome entry site (IRES), structurally similar to although highly divergent in sequence from that of HCV and other hepaciviruses. However, phylogenetic analysis of nonstructural genes (NS3 and NS5B) showed that HHpgV-1 forms a branch within the pegivirus clade distinct from HPgV and homologs infecting other mammalian species. In common with some pegivirus variants infecting rodents and bats, the HHpgV-1 genome encodes a short, highly basic protein upstream of E1, potentially possessing a core-like function in packaging RNA during assembly.
The researchers say that identification of this new human virus, HHpgV-1, expands knowledge of the range of genome configurations of these viruses and may lead to a re-evaluation of the original criteria by which the genera Hepacivirus and Pegivirus are defined.
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Reference: Kapoora A, Kumara A, et al. Virome Analysis of Transfusion Recipients Reveals a Novel Human Virus That Shares Genomic Features with Hepaciviruses and Pegiviruses. mBio. 6(5):e01466-15. doi:10.1128/mBio.01466-15.
