Nickel is the Key to H. pylori Pathogenesis

Professor Frédéric Veyrier's most recent research, in collaboration with the team of professor Hilde De Reuse at the Institut Pasteur, has shed light on key genes essential to the pathogenesis of Helicobacter pylori bacterium, which causes gastric infections. Like other microorganisms, this pathogen underwent genetic modifications through the course of evolution that enabled it to adapt to its environment.

Nickel is in fact the evolutionary key that allows the pathogen to survive the very acid conditions of the stomach. This metal is a cofactor of two essential proteins, one of which is urease, an enzyme that neutralizes gastric acid. Therefore, to colonize the stomach, the pathogen needs an efficient nickel transport system. By examining the bacterium's entire genome, the research team identified a new nickel transporter that appears to be essential for the metal acquisition. Once inside the bacterial cell, nickel regulates the synthesis of urease, which in turn neutralizes the acid from the stomach. This gene, along with a number of other genes encoding proteins involved in nickel homeostasis, has been acquired a long time ago by the bacterium via horizontal gene transfer.

Metals are often key players during bacterial pathogenesis. It is the case for many other microorganisms, including pathogenic strains of Escherichia coli, in which iron plays a major role in its ability to infect the host. However, the genetic reshuffling leading to metal homeostasis modifications in Helicobacter pylori and allowing it to adapt to the gastric environment seems to be quite unique.

Further genetic studies should enable researchers to identify other genes that have been dropped or acquired through evolution, giving microorganisms the characteristics they need to colonize their hosts and cause disease.

Source: Institut national de la recherche scientifique - INRS