Aggressive infections in hospitals are an increasing health problem worldwide. Now, a young Danish scientist has found a natural substance in a Chilean rainforest plant that effectively supports the effect of traditional treatment with antibiotics.
Â
Jes Gitz Holler, from the University of Copenhagen, discovered in a research project a compound that targets a particular resistance mechanism in Staphylococcus aureus. The development of resistance in these specific bacteria is extremely rapid. Bacterial strains that do not respond to treatment have already been found in the U.S. and Greece.
Â
"I have discovered a natural substance in a Chilean avocado plant that is active in combination treatment with traditional antibiotics. Resistant bacteria have an efflux pump in their bacterial membrane that efficiently pumps out antibiotics as soon as they have gained access. The identified natural substance inhibits the pumping action, so that the bacterias defence mechanisms are broken down and the antibiotic treatment allowed to work," explains Holler.
Â
Holler gathered specimens of the plant, which comes from the Persea family, in Chile, where the Mapuche people use the leaves of the avocado plant to heal wounds. The results have been published in Journal of Antimicrobial Chemotherapy.
 Â
The so-called MIC value is the lowest possible concentration of an antibiotic that inhibits the bacterial growth. With his compound from the medicine chest of the Mapuche people, Holler can lower the MIC value by at least eight times: "The natural compound has great potential and perhaps in the longer term can be developed into an effective drug to combat resistant staphylococci. At this time there are no products on the market that target this same efflux-inhibitor mechanism. We want to improve the active substance using synthetic chemistry in the laboratory. That will also ensure sustainable production of a potential drug while protecting rainforest plants."
Holler emphasises that a commercial product will benefit the Mapuche people. At present there is a written agreement between the faculty of Health and Medical Sciences and the representative of the Mapuche people, Alfonso Guzmán, PhD, who helped procure the plant material.
 Â
Staphylococcus aureus is the most common cause of infection in wounds from an operation; however, the bacteria can be the cause of many diseases, from abscesses and food poisoning to life-threatening infections such as infective endocarditis and sepsis. The bacteria have been a major problem in hospitals worldwide since the 1940s, and up to now the drug industry has managed to develop new antibiotics in step with the increasingly aggressive behaviour of the bacteria. Unfortunately, that development appears to be turning:
Â
"For all intents and purposes, the drug industry is not pursuing research into new antibiotics. It is simply too expensive relative to possible earnings, and there is more money in drugs to treat chronic diseases such as diabetes. Therefore, the bacteria are winning the race resistance increases and treatment options are scarce. Research will have to find new paths and natural substances are one of them," says Holler.
Â
Beyond the Surface: Rethinking Environmental Hygiene Validation at Exchange25
June 30th 2025Environmental hygiene is about more than just shiny surfaces. At Exchange25, infection prevention experts urged the field to look deeper, rethink blame, and validate cleaning efforts across the entire care environment, not just EVS tasks.
A Controversial Reboot: New Vaccine Panel Faces Scrutiny, Support, and Sharp Divides
June 26th 2025As the newly appointed Advisory Committee on Immunization Practices (ACIP) met for the first time under sweeping changes by HHS Secretary Robert F. Kennedy Jr, the national spotlight turned to the panel’s legitimacy, vaccine guidance, and whether science or ideology would steer public health policy in a polarized era.
Getting Down and Dirty With PPE: Presentations at HSPA by Jill Holdsworth and Katie Belski
June 26th 2025In the heart of the hospital, decontamination technicians tackle one of health care’s dirtiest—and most vital—jobs. At HSPA 2025, 6 packed workshops led by experts Jill Holdsworth and Katie Belski spotlighted the crucial, often-overlooked art of PPE removal. The message was clear: proper doffing saves lives, starting with your own.