The new normal in infection prevention revolves around data collection and number crunching, with the ultimate goal of determining progress in organizational quality improvement. Addressing the criticality of surface disinfection and environmental hygiene, which is a cornerstone of infection prevention and control, is just one part of the bigger picture of healthcare-acquired infection (HAI) prevention. It is essential that infection preventionists recognize and understand the changing landscape of healthcare delivery that requires healthcare facilities to meet new financial incentives to avoid HAIs and other conditions that impact patient outcomes. This slide show presents highlights from a special report, HAI Prevention and Environmental Hygiene: The Changing Landscape of Healthcare Delivery, sponsored by PDI.