Successful Antibody Trial in HIV-Infected Individuals

Article

A research team led by investigators of the Rockefeller University in New York and professor Florian Klein, University Hospital Cologne and German Center for Infection Research (DZIF), has tested a new HIV neutralizing antibody, called 10-1074, in humans. The results of the trial have just been published in Nature Medicine.

Over the last years, a new generation of HIV neutralizing antibodies was identified. "These antibodies are highly potent and are able to effectively neutralize a large number of different HIV strains. Therefore, they play an important role in the quest for and development of an HIV vaccine," explains Klein. Additionally, in close collaboration with the Division of Infectious Diseases at the University Hospital Cologne and scientists of the Rockefeller University in New York, Klein's research group is investigating whether broadly neutralizing antibodies can be used to treat HIV infection.

The just published trial investigates this approach. The broadly neutralizing antibody 10-1074 targets a specific structure (V3 loop) on the HIV envelope protein. In the study, the investigators show that the antibody was well tolerated and demonstrated favorable pharmacokinetic properties. Additionally, the antibody showed high antiviral activity in the participants with HIV infection. Furthermore, the team was able to specifically investigate the development of resistant HIV variants. "We performed a comprehensive HIV sequence analysis to investigate the dynamics and mechanisms HIV uses to escape the selection pressure by the antibody," says Dr. Henning Gruell, one of the first authors of the current publication.

"This trial was only possible because of the intensive collaboration with the Rockefeller University and many other clinical and scientific partners," says Klein, principal investigator in Germany and co-last author of the study. The scientists are planning further trials to investigate an antibody-mediated treatment approach in patients with HIV infection. Further trials have already been scheduled for spring.

Reference: Caskey, Schoofs, and Gruell et al. Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nature Medicine (2017) doi:10.1038/nm.4268

Source: German Center for Infection Research

Recent Videos
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Mark Wiencek, PhD
Rebecca Crapanzano-Sigafoos, DrPH, CIC, AL-CIP, FAPIC
The CDC’s updated hospital respiratory reporting requirement has added new layers of responsibility for infection preventionists. Karen Jones, MPH, RN, CIC, FAPIC, clinical program manager at Wolters Kluwer, breaks down what it means and how IPs can adapt.
Studying for the CIC using a digital tablet and computer (Adobe Stock 335828989 by NIKCOA)
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Cheron Rojo, BS, FCS, CHL,  CER, CFER, CRCST
Matthias Tschoerner, Dr Sc
Standardizing Cleaning and Disinfection
Related Content