Most Preventive Antibiotics Prescribed by Dentists are Unnecessary

June 1, 2019

A new study conducted by researchers at the University of Illinois at Chicago and published in JAMA Network Open has found that 81 percent of antibiotics prescribed by dentists -- who are among the top prescribers in the U.S., accounting for about 10 percent of all antibiotic prescriptions -- to prevent infections prior to dental visits are unnecessary.

The researchers, led by Katie Suda, associate professor of pharmacy systems, outcomes and policy at the UIC College of Pharmacy, say that this surprising finding highlights the need for improved antibiotic stewardship in dental practices, especially those located in the Western U.S., which were associated with the highest rates of unnecessary prescribing.

Using Truven, a national integrated health claims database, the researchers retrospectively analyzed dental visits occurring between 2011 and 2015. They compared antibiotic prescriptions -- which were dispensed prior to 168,420 dental visits -- to the number of high-risk cardiac patients who, per national guidelines, are the only patients recommended for antibiotics prior to a dental procedure.

They found that 81 percent of prescriptions did not align with the national guidelines and were provided for patients without high-risk cardiac conditions.

"Use of preventive antibiotics in these patients opens them up to the risks associated with antibiotic use -- increasing bacterial resistance and infections, for example -- when the evidence used to develop the guidelines suggests that the risks outweigh the benefits in most patients," said Suda, the corresponding author on the study.

The researchers also looked at dentists' antibiotic prescribing patterns by geography. They found that the Western U.S. and urban areas were more likely to have unnecessary prescribing. Among patients most likely to fill prescriptions for unnecessary antibiotics are those with prosthetic joint implants and those receiving clindamycin.

"These results point to trends by geography that are unexpected -- they are the opposite of what is seen in medical clinics -- and to an alarming tendency of dental providers to select clindamycin, which is associated with a higher risk of developing C. difficile infections when compared to some other antibiotics," Suda said.

UIC's Susan Rowan, a dentist, worked with Suda on the research.

"Dental providers are very thoughtful when they develop care plans for their patients and there are many factors that inform dentists' recommendations and the medications they prescribe, but this study shows that there is an opportunity for dentists to reevaluate if necessary and incorporate renewed commitments to antibiotic stewardship into their practices that limit preventive prescriptions to a small group of patients," said Rowan, executive associate dean and associate dean for clinical affairs at the UIC College of Dentistry. "I think dental providers should view this study, which is the first to look at preventive antibiotic prescribing for dental procedures and provide this type of actionable information, as a powerful call to action, not a rebuke."

The authors noted that because the study was limited to patients with commercial dental insurance and the analysis used a broad definition of high-risk cardiac patients, the findings may actually underestimate unnecessary prescribing of antibiotics.

Additional co-authors on the study, which was funded by the Agency for Healthcare Research and Quality (R01HS25177), include Gregory Calip, Dr. Jifang Zhou, Alan Gross, Dr. Ronald Hershow and Rose Perez of UIC; Jessina McGregor of Oregon State University; and Charlesnika Evans of Northwestern University.

Source: University of Illinois at Chicago