New research has shown for the first time that the spread of multi drug-resistant tuberculosis (TB) can be halted through a well executed standard treatment program.
Bacterial fingerprinting techniques used to track disease transmission in a southern Mexico community revealed that all categories of tuberculosis were controlled when the directly observed therapy (DOTS) strategy was used.
DOTS is the strategic approach which has been used to treat more than 17 million people since its adoption by the World Health Organization in 1991. It is based on; political commitment, accurate diagnosis, standardized drug treatment and monitoring of treatment results. But until now its ability to control the infectious disease in areas afflicted by multi-drug resistant strains had not been rigorously tested.
TB still kills 2 million people a year -- one death every 15 seconds -- and there are growing levels of multi-drug resistance in Africa and Europe.
This latest study, which comes just a week after World TB Day, was conducted by an international team of researchers from Mexicos National Institutes and Stanford University, and is published in this weeks edition of The Lancet. It shows that despite a moderate level of multi-drug resistant TB, the DOTS program interrupted disease transmission in the Orizaba Health Jurisdiction, Veracruz.
At the beginning of the study in 1995, 22 percent of previously untreated patients were carrying drug-resistant strains and 6.7 percent had multi-drug resistance. By 200, only 7.8 percent had drug-resistant strains and there were no cases of MDR-TB.
The researchers, who were funded by the Wellcome Trust, The Howard Hughes Medical Institute and the U.S. National Institute of Allergy and Infectious Diseases, also found that the rate of pulmonary TB among their 436 patients fell by 54 percent from 42 to 19 per 100,000 of the population. Despite DOTS, however, 12 percent of those with MDR tuberculosis died.
Dr. Alfredo Ponce de Leon from Mexicos National Institute of Medical Sciences and Nutrition, said, The spread of multi-drug resistant TB is potentially devastating. Our study is great news for the world -- in many settings implementing standard TB control can prevent this spread. However, it also amplifies the tragic fact that fewer than half of the worlds TB cases have access to this basic care.
Dr. Peter Small from Stanford University commented, Our data show that DOTS is an essential public health intervention. But even with this program the number of people dying from multi-drug resistant TB remains unacceptable, highlighting the desperate need for new tools to save the lives of the hundreds of thousands of people who are suffering from it.
Happy Hand Hygiene Day! Rethinking Glove Use for Safer, Cleaner, and More Ethical Health Care
May 5th 2025Despite their protective role, gloves are often misused in health care settings—undermining hand hygiene, risking patient safety, and worsening environmental impact. Alexandra Peters, PhD, points out that this misuse deserves urgent attention, especially today, World Hand Hygiene Day.
From the Derby to the Decontam Room: Leadership Lessons for Sterile Processing
April 27th 2025Elizabeth (Betty) Casey, MSN, RN, CNOR, CRCST, CHL, is the SVP of Operations and Chief Nursing Officer at Surgical Solutions in Overland, Kansas. This SPD leader reframes preparation, unpredictability, and teamwork by comparing surgical services to the Kentucky Derby to reenergize sterile processing professionals and inspire systemic change.
Show, Tell, Teach: Elevating EVS Training Through Cognitive Science and Performance Coaching
April 25th 2025Training EVS workers for hygiene excellence demands more than manuals—it requires active engagement, motor skills coaching, and teach-back techniques to reduce HAIs and improve patient outcomes.
The Rise of Disposable Products in Health Care Cleaning and Linens
April 25th 2025Health care-associated infections are driving a shift toward disposable microfiber cloths, mop pads, and curtains—offering infection prevention, regulatory compliance, and operational efficiency in one-time-use solutions.