Cornell University researchers have discovered there is a division of labor among immune cells that fight invading pathogens in the body.
The study, published in the journal Cell, finds for the first time that fetal immune cells are present in adults and have specialized roles during infection. In fact, the first immune cells made in early life are fast-acting first responders to microbes in adulthood.
These immune cells - called CD8+ T cells - come in fetal and adult varieties, which originate in separate parts of the body and are hardwired with intrinsically different properties. The current paradigm is that, around the time of birth, the body switches from making and using fetal T cells to adult T cells to defend itself. But Cornell researchers used a unique study design to show that fetal T cells persist into adulthood and have different roles than adult cells in fighting infection.
"This discovery has led to the new idea that we might be able to predict how individuals will respond to infection based on how many fetal cells are present in the adult pool and isolate the fast-acting fetal-derived cells for certain therapeutic interventions, such as infections and cancer immunotherapy," said Brian Rudd, associate professor of immunology in the College of Veterinary Medicine and the paper's senior author. Norah Smith, a research associate in Rudd's lab, is the paper's first author.
In adults, newly formed T cells recognize a signature protein on a pathogen when they first encounter it. That signal then activates the T cells and equips them to fight and proliferate up to 15 times, producing up to 10 million cells in a week. Once the pathogen has been cleared, most of those adult T cells die, but up to 10 percent survive and are stored in a pool of memory cells, allowing for a rapid recall response if that same pathogen were to strike again.
Fetal-derived cells, on the other hand, are generalists and do not form into memory cells. They respond to inflammatory signals and activate faster than adult T cells, allowing them to provide a broad swath of protection against pathogens they don't specifically recognize, Rudd said.
"It's the way that the immune system hedges its bet: It has cells that can respond at different rates," Rudd said.
Future work will explore how genetic and environmental factors, such as diet and gut bacteria, may alter the developmental layers in the immune system.
The study was funded by the National Institutes of Health and the National Health and Medical Research Council in Australia.
Source: Cornell University
Stay prepared and protected with Infection Control Today's newsletter, delivering essential updates, best practices, and expert insights for infection preventionists.
Reducing Hidden Risks: Why Sharps Injuries Still Go Unreported
July 18th 2025Despite being a well-known occupational hazard, sharps injuries continue to occur in health care facilities and are often underreported, underestimated, and inadequately addressed. A recent interview with sharps safety advocate Amanda Heitman, BSN, RN, CNOR, a perioperative educational consultant, reveals why change is overdue and what new tools and guidance can help.
New Study Explores Oral Vancomycin to Prevent C difficile Recurrence, But Questions Remain
July 17th 2025A new clinical trial explores the use of low-dose oral vancomycin to prevent Clostridioides difficile recurrence in high-risk patients taking antibiotics. While the data suggest a possible benefit, the findings stop short of statistical significance and raise red flags about vancomycin-resistant Enterococcus (VRE), underscoring the delicate balance between prevention and antimicrobial stewardship.
What Lies Beneath: Why Borescopes Are Essential for Verifying Surgical Instrument Cleanliness
July 16th 2025Despite their smooth, polished exteriors, surgical instruments often harbor dangerous contaminants deep inside their lumens. At the HSPA25 and APIC25 conferences, Cori L. Ofstead, MSPH, and her colleagues revealed why borescopes are an indispensable tool for sterile processing teams, offering the only reliable way to verify internal cleanliness and improve sterile processing effectiveness to prevent patient harm.
The Next Frontier in Infection Control: AI-Driven Operating Rooms
Published: July 15th 2025 | Updated: July 15th 2025Discover how AI-powered sensors, smart surveillance, and advanced analytics are revolutionizing infection prevention in the OR. Herman DeBoard, PhD, discusses how these technologies safeguard sterile fields, reduce SSIs, and help hospitals balance operational efficiency with patient safety.
Targeting Uncertainty: Why Pregnancy May Be the Best Time to Build Vaccine Confidence
July 15th 2025New national survey data reveal high uncertainty among pregnant individuals—especially first-time parents—about vaccinating their future children, underscoring the value of proactive engagement to strengthen infection prevention.