A little-explored group of immune cells plays an important role in the regulation of intestinal bacteria. Changing metabolic states of the microbes have an effect on defense cells at different stages of alert or rest, as researchers from the Department of Biomedicine at the University and University Hospital of Basel report in the journal Mucosal Immunology.
It is known that the metabolites of bacteria influence the composition and function of immune cells resident within the gut. These defense cells include MAIT cells (mucosal-associated invariant T cells), which were only recently discovered and are naturally abundant in the gastrointestinal mucosa, skin liver and blood. These cells are specialized in recognizing the microorganisms living in every human being and monitoring their activities.
A group led by Dr. Gennaro De Libero from the University of Basel and Dr. Petr Hruz from the University Hospital of Basel have investigated how MAIT cell activation and function is influenced by bacterial metabolites produced in normal colon. The study revealed that distinct populations of MAIT cells are located in the human intestinal mucosa. These populations were identified in gut biopsies using highly innovative methods and bioinformatics analyses.
Result: MAIT cells are present in variable states of alert and rest, in accordance with the metabolic state of intestinal bacterial flora. The defense cells are most frequently stimulated by bacteria grown under low-oxygen and slow growth-phase - conditions such as those found in the large intestine. MAIT cells can then directly influence local inflammation but also tissue healing and cell fitness in the gut by producing different messenger substances.
"Our results show that there is a fine balance occurring in the gut between microbial growth conditions, the production of stimulating metabolites and the response of MAIT defense cells," state the researchers. The metabolism of microbes in the intestine constantly adapts to changing host conditions. By detecting the metabolic state of enteric bacteria, MAIT cells can potentiate their function in mucosal immunosurveillance.
Source: University of Basel
Beyond the Surface: Rethinking Environmental Hygiene Validation at Exchange25
June 30th 2025Environmental hygiene is about more than just shiny surfaces. At Exchange25, infection prevention experts urged the field to look deeper, rethink blame, and validate cleaning efforts across the entire care environment, not just EVS tasks.
A Controversial Reboot: New Vaccine Panel Faces Scrutiny, Support, and Sharp Divides
June 26th 2025As the newly appointed Advisory Committee on Immunization Practices (ACIP) met for the first time under sweeping changes by HHS Secretary Robert F. Kennedy Jr, the national spotlight turned to the panel’s legitimacy, vaccine guidance, and whether science or ideology would steer public health policy in a polarized era.
Getting Down and Dirty With PPE: Presentations at HSPA by Jill Holdsworth and Katie Belski
June 26th 2025In the heart of the hospital, decontamination technicians tackle one of health care’s dirtiest—and most vital—jobs. At HSPA 2025, 6 packed workshops led by experts Jill Holdsworth and Katie Belski spotlighted the crucial, often-overlooked art of PPE removal. The message was clear: proper doffing saves lives, starting with your own.