Persistence is the cornerstone of the methicillin-resistant Staphylococcus aureus (MRSA) prevention program at Nash Health Care. Through a multidisciplinary approach, the system focused intensely on hand hygiene, contact precautions and environmental cleaning. Staff also felt that if they focused on MRSA, which causes high-profile healthcare-associated infections (HAIs), these control measures would also have an impact on other multidrug-resistant organisms as well.