Researchers Find Age Not a Factor in Immunity to Viruses

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Our immune system does not shut down with age, according to a new study led by McMaster University researchers.

A study published in PLOS Pathogens today shows a specialized class of immune cells, known as T cells, can respond to viral infections in an older person with the same vigor as T cells from a young person.

For a long time, it was thought the elderly were at a higher risk of infections because they lacked these immune cells, but that simply isnt the case, says Jonathan Bramson, the studys principal investigator. The elderly are certainly capable of developing immunity to viruses.


Researchers at McMaster, University of Toronto and the University of Pennsylvania examined individuals, younger than 40, between 41 to 59 years of age and older than 60, infected with three different viruses, including West Nile, and found the older group demonstrated perfectly normal immune responses.

Both the number of virus-fighting T cells and the functionality of the T cells were equivalent in all three groups.

So as we age, our bodies are still able to respond to new viruses, while keeping us immune to viruses weve been exposed to in the past, Bramson says.

He adds that these results have important implications for vaccination of elderly individuals. Currently, vaccines for the elderly arent designed to elicit responses from these immune cells, and this might explain the lack of effective protection from the flu vaccine, he said.

Vaccines specifically designed to generate T-cell immunity may be more effective at protecting older adults, Bramson says.

The research was funded by the Canadian Institutes for Health Research and the U.S. National Institutes of Health. PLOS Pathogens is an open-access, peer-reviewed journal of the Public Library of Science.