Rotavirus and Pneumococcal Conjugate Vaccines Reduce Pediatric Hospital Burden

Researchers show that the introduction of both pneumococcal conjugate vaccines (PCVs) and rotavirus vaccines (RVs) led to the rapid and dramatic reduction in hospital burden of both winter diarrhea and respiratory infections within <5 years post introduction of the vaccines. This research is presented at ASM's 55th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC/ICC).

"Our findings confirm the utmost importance of co-contribution of pneumococcal and rotavirus vaccines in reduction of burden of severe diarrhea and respiratory diseases reduction, especially during winter, the season with peak hospitalization rates of young children," says principal investigator, Ron Dagan, MD, professor of pediatrics and infectious diseases in the Pediatric Infectious Disease Unit at Soroka University Medical Center, Israel.

Winter respiratory and diarrheal diseases in infants and young children are often due to infections caused by the bacterium Streptococcus pneumoniae (the pneumococcus) and the rotavirus, respectively. New vaccines against pneumococcus (pneumococcal conjugate vaccines [PCVs]) and against rotavirus were recently introduced and each showed great impact on the disease it was addressed to reduce. However, the combined impact resulting from the introduction of both vaccines on hospital burden, especially during the very busy fall and winter season, was not fully studied.

This study aimed to observe the combined effect of the co-administration of PCVs and rotavirus vaccines was part of an enhanced prospective surveillance which took place in southern Israel, by the group led by Ron Dagan, MD, from the Pediatric Infectious Disease Unit of the Soroka University Medical Center and the Faculty of Health Sciences at the Ben-Gurion University in Beer-Sheva, Israel.

Within <5 years from introduction, the rate of hospital admission due to rotavirus diarrhea in children younger than two years dropped by 78 percent and that of children < 2 years with X-ray proven pneumonia dropped by 46 percent. For outpatient visits these figures were 80 percent and 67 percent, respectively. These figures translate into reduction of 21.5 yearly pediatric hospitalizations per 1,000 children <2 years (11.1 and 10.4 visits for diarrhea and respiratory diseases, respectively), and 20.7 yearly emergency-room visits per 1,000 children < 2 years (11.4 and 9.3 for diarrhea and respiratory infections, respectively).

Extrapolated to the birth cohort in the U.S. (~4 million births), the yearly reduction in hospitalization burden for respiratory infection and diarrhea is ~86,000 and for pediatric outpatient emergency visits it is ~82,500 episodes (reducing altogether ~168,000 hospital visits yearly). Moreover, >70 percent of these numbers are during the late fall and the winter months - where most of hospitalization burden occurs in young children.

The study was funded in part by the rotavirus and pneumocccal vaccine manufacturers, and was a part of the evaluation plan of vaccine introduction of the Israel Ministry of Health.

This research was presented as part of ASM's Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) being held Sept. 17-21, 2015 in San Diego.

Source: American Society for Microbiology