A new University of Texas at Arlington study about the elimination of malaria in the 1930s American South may have significant implications for solving modern day malaria outbreaks in parts of Africa, Central and Latin America, and Asia.
Â
Researchers challenged a leading argument that movement of Southern tenant farmers away from mosquito breeding grounds was the dominant factor in the decline of malaria in U.S. during the 1930s.
Â
Instead, targeted public health interventions and the development of local-level public health infrastructure helped eradicate the disease, according to Daniel Sledge, assistant professor of political science at UT Arlington and lead author of Eliminating Malaria in the American South: An Analysis of the Decline of Malaria in 1930s Alabama, a paper recently published by the American Journal of Public Health.
Â
We found that targeted public health interventions, supported by the federally backed development of state and local public health infrastructure, led to the decline of malaria despite widespread and deep-seated poverty, Sledge says.
Â
Beth Wright, dean of the College of Liberal Arts at UT Arlington, says Sledges research benefits the public, health professionals and policy makers globally. Dr. Sledges work has far-reaching implications for those who work to eradicate malaria and similar diseases, Wright said. Huge challenges remain, but such research brings about better understanding of potential solutions and could ultimately help save lives.
Â
Malaria is an infectious disease caused by a parasite called plasmodium and transmitted through the bites of infected mosquitoes. The disease causes fever, headache, and vomiting. Untreated, it can become life threatening.
Â
Malaria killed an estimated 1.24 million worldwide in 2010 and decimated economies in the heavily populated, warm climate regions of the Global South, according to recent studies. Malaria played a similarly devastating role in the American South until the 1930s, researchers detailed, by lowering the productivity of workers, deterring migration into the region and severely limiting economic growth.
Â
Historian Margaret Humphreys argued in her landmark 2001 book, Malaria: Race, Poverty, and Public Health in the United States, that it was the removal of the malaria carrier and victim from the vicinity of the anopheles mosquito that likely had the largest effect on the decline of the disease.
Â
But Sledge and co-author George Mohler, assistant professor of mathematics and computer science at Santa Clara University in California, found otherwise.
Â
We assessed this argument using Census data on the number of farms operated by tenants during the 1930s. We found that highly malarial areas actually gained population during the period that malaria declined, Sledge says. Changes in the type of farms, meanwhile, didnt lead to a decline in malaria. Put another way, population movement didnt lead to the end of malaria in the United States public health work did.
Â
During the 1930s, the federal Works Progress Administration put unemployed Southerners to work draining millions of acres of wetlands. Along with the federally sponsored creation of local health departments, these drainage projects led to the decline of malaria, the authors said.
Â
The federal government further ramped up its efforts during World War II, creating the agency that became the Centers for Disease Control and Prevention specifically to fight southern malaria. After the war, the CDC used the insecticide DDT to eradicate the few remaining pockets of the disease.
Â
For their study, Sledge and Mohler used a mathematical model to analyze the decline of malaria in each of the 67 counties in Alabama, an archetypical Deep South cotton state that experienced high levels of malaria incidence well into the 1930s.
Â
In the model, we categorized counties into three risk levels and then estimated the dependence of mortality rates on variables related to weather, WPA projects, and population movement, Mohler says. After drought, the most important variable for predicting a decline in mortality rates was the amount of drainage in a county, rather than movement out of high risk counties or a reduction in tenant farms.
Â
In addition to drainage work, researchers point to the importance of measures such as screening and public health infrastructure as well as the training of public health workers in the elimination of the disease.
Â
While the team concedes that there are considerable distinctions between the current Global South and the American South of the 1930s, they argue that malaria can be controlled in the face of poverty and economic dislocation and without major social change.
Â
Today, disease surveillance, drainage measures and screening work to ensure that, on those occasions when malaria is reintroduced from outside of the U.S., the chain of transmission does not begin again, Sledge says.
Source: University of Texas at Arlington Â
Stay prepared and protected with Infection Control Today's newsletter, delivering essential updates, best practices, and expert insights for infection preventionists.
Reducing Hidden Risks: Why Sharps Injuries Still Go Unreported
July 18th 2025Despite being a well-known occupational hazard, sharps injuries continue to occur in health care facilities and are often underreported, underestimated, and inadequately addressed. A recent interview with sharps safety advocate Amanda Heitman, BSN, RN, CNOR, a perioperative educational consultant, reveals why change is overdue and what new tools and guidance can help.
New Study Explores Oral Vancomycin to Prevent C difficile Recurrence, But Questions Remain
July 17th 2025A new clinical trial explores the use of low-dose oral vancomycin to prevent Clostridioides difficile recurrence in high-risk patients taking antibiotics. While the data suggest a possible benefit, the findings stop short of statistical significance and raise red flags about vancomycin-resistant Enterococcus (VRE), underscoring the delicate balance between prevention and antimicrobial stewardship.
What Lies Beneath: Why Borescopes Are Essential for Verifying Surgical Instrument Cleanliness
July 16th 2025Despite their smooth, polished exteriors, surgical instruments often harbor dangerous contaminants deep inside their lumens. At the HSPA25 and APIC25 conferences, Cori L. Ofstead, MSPH, and her colleagues revealed why borescopes are an indispensable tool for sterile processing teams, offering the only reliable way to verify internal cleanliness and improve sterile processing effectiveness to prevent patient harm.
The Next Frontier in Infection Control: AI-Driven Operating Rooms
Published: July 15th 2025 | Updated: July 15th 2025Discover how AI-powered sensors, smart surveillance, and advanced analytics are revolutionizing infection prevention in the OR. Herman DeBoard, PhD, discusses how these technologies safeguard sterile fields, reduce SSIs, and help hospitals balance operational efficiency with patient safety.
Targeting Uncertainty: Why Pregnancy May Be the Best Time to Build Vaccine Confidence
July 15th 2025New national survey data reveal high uncertainty among pregnant individuals—especially first-time parents—about vaccinating their future children, underscoring the value of proactive engagement to strengthen infection prevention.