Study Reveals the High Cost of Norovirus Worldwide

While norovirus is often linked in the news to outbreaks on cruise ships, the highly contagious stomach bug sickens nearly 700 million around the world every year and results in roughly $4.2 billion in healthcare costs and $60.3 billion in societal costs annually, new Johns Hopkins Bloomberg School of Public Health research suggests.

The findings, published April 26 in PLOS ONE, are believed to be the first to look at the global economic burden of norovirus, which is common in both wealthy and poor nations. The researchers say their study suggests that much more attention and education are needed to combat a disease that also kills approximately 219,000 a year around the world.

“You only seem to hear about it when people get sick on a cruise ship or at a restaurant, but norovirus is everywhere,” says study leader Sarah M. Bartsch, MPH, a research associate at the Bloomberg School. “It doesn’t matter how old you are or if you’re in a wealthy country or a poorer one or if you’ve had it before – you can get it again. And it is really unpleasant. But if we don’t focus on norovirus and teach people how to prevent it, little headway will be made to combat it.”

Says the study’s senior author, Bruce Y. Lee, MD, MBA, an associate professor in the Department of International Health at the Bloomberg School: “The costs associated with norovirus are high - higher than for many diseases, including rotavirus, that have gotten a lot more attention. Our study presents an economic argument for greater consideration of norovirus. It has been flying under the radar for too long.”

Norovirus is an easily transmissible virus that can cause severe gastrointestinal symptoms, including nausea, diarrhea and vomiting. While it is most often discussed in relation to outbreaks, less than one percent of cases are associated with outbreaks. The researchers say that norovirus is not routinely tested for and the number of cases may be an underestimate. There is not yet a vaccine or a treatment for norovirus.

In contrast, the burden of rotavirus, a diarrheal disease that kills many babies but rarely endangers anyone over age five, was estimated at $2 billion a year before a vaccine was rolled out.

For their study, the researchers developed a computer model to estimate both the costs of the medical burden (such as clinic visits and hospitalizations) and the other economic costs, most notably loss of productivity. Productivity losses are due to missed work due to illness, caring for a sick child, underperforming at work while sick and premature mortality. Their model estimated the cost for 233 countries, regions and territories in the world for which the United Nations has population data.

“Lost productivity is a big part of the cost," Lee says. “By just focusing on health care costs, or simple measures such as death caused by the disease, we miss a lot of the burden. Productivity losses tend to go unrecognized, but make up 94 percent of the global economic burden of norovirus.”

The researchers say they hope their work will inform funding agencies and public health bodies regarding where to best allocate limited resources for intervention and control measures, including educational measures to prevent its spread.

Proper handwashing, maintaining health precautions during food preparation, improving food and water sources and keeping those who are sick with norovirus from coming into contact with others are some methods for protecting against the disease. The high costs associated with norovirus demonstrate the potential value of developing new technologies and approaches to detect, prevent and treat norovirus infections.

This work was supported by the Agency for Healthcare Research and Quality (R01HS023317), the Eunice Kennedy Shriver National Institute of Child Health and Human Development Office of Behavioral and Social Sciences Research (U54HD070725) and the Global Obesity Prevention Center at the Bloomberg School.

“Global Economic Burden of Norovirus Gastroenteritis” was written by Sarah M. Bartsch, MPH; Benjamin A. Lopman, PhD; Sachiko Ozawa, MHS, PhD; Aron J. Hall, DVM, MSPH; and Bruce Y. Lee, MD, MBA.

Source: Johns Hopkins Bloomberg School of Public Health