A study by researchers at the University of California, San Diego (UCSD) School of Medicine shows that fluctuations in Vitamin D3 levels control the bodys innate immune response, affecting a skin wounds ability to heal.
Richard L. Gallo, MD, PhD, professor of medicine and chief of UCSDs Division of Dermatology and the Dermatology section of the Veterans Affairs San Diego Healthcare System, says that several unexpected associations between fluctuations of the bodys vitamin D3 and infectious disease have emerged in recent investigations.
In a study appearing online February 8 in advance of publication in the March issue of the Journal of Clinical Investigation, Gallo and his colleagues look at how the innate immune system is controlled in the skin, and find that genes controlled by active vitamin D3 play an essential role in the process.
Our study shows that skin wounds need vitamin D3 to protect against infection and begin the normal repair process, said Gallo. A deficiency in active D3 may compromise the bodys innate immune system which works to resist infection, making a patient more vulnerable to microbes.
Gallos lab discovered that an antimicrobial peptide called cathelicidin is produced by wounds and is necessary to fight infections. Recently, several studies have begun to link vitamin D to cathelicidin. Researchers focused on white blood cells called macrophages that work to destroy invading bacterial microbes.
Macrophages contain toll-like receptors that identify the invaders; when the receptors sense the presence of bacteria, they trigger cathelicidin production.
Gallos team has now discovered that injury stimulates skin cells called keratinocytes, which surround the wound, to increase the production of vitamin D3 and that this in turn increases the expression of genes (CD14 and TLR2) that detect microbes. These genes, together with active vitamin D3, called 1,25D3, then lead to more cathelicidin. In both mice and humans, a deficiency in cathelicidin allows infections to develop more readily.
Our finding that multiple, diverse genes controlled by 1,25D3 are increased after injury to the skin suggests that the availability of D3 is essential to the wound. These responses are a previously unrecognized part of the human injury response, said Gallo.
Lower concentrations of 1,25D3 in African-Americans, likely due to a decreased ability to absorb vitamin D from sunlight, correlate with increased susceptibility to infection. In addition, 1,25D3 has been suggested to be an immune-modifying agent in pulmonary tuberculosis.
As a result of this and previous studies, Gallo and his colleagues are beginning clinical trials at UCSDMedicalCenter with both oral and topical vitamin D3. Normal volunteers, and patients with disorders in antimicrobial peptide production such as atopic dermatitis and acne, are being studied to determine if vitamin D3 can improve their natural immune defenses.
Additional contributors to the paper include Jürgen Schauber, Robert A. Dorschner, Alvin B. Coda, Amanda S. Büchau and David Kiken of UCSDs Division of Dermatology and VA San Diego Healthcare System; Philip T. Liu and Robert L. Modlin, Division of Dermatology, David Geffen School of Medicine, UCLA; Yolanda R. Helfrich and Sewon Kang Department of Dermatology, University of Michigan; Hashem Z. Alalieh and Daniel D. BIkle, Department of Medicine, VA Medical Center, UCSF; Andreas Steinmeyer and Ulrich Zügel, Schering AG, Berlin, Gemany
The research was sponsored by the National Institutes of Health and the Veterans Administration.
Source: UCSD
Stay prepared and protected with Infection Control Today's newsletter, delivering essential updates, best practices, and expert insights for infection preventionists.
Reducing Hidden Risks: Why Sharps Injuries Still Go Unreported
July 18th 2025Despite being a well-known occupational hazard, sharps injuries continue to occur in health care facilities and are often underreported, underestimated, and inadequately addressed. A recent interview with sharps safety advocate Amanda Heitman, BSN, RN, CNOR, a perioperative educational consultant, reveals why change is overdue and what new tools and guidance can help.
The Next Frontier in Infection Control: AI-Driven Operating Rooms
Published: July 15th 2025 | Updated: July 15th 2025Discover how AI-powered sensors, smart surveillance, and advanced analytics are revolutionizing infection prevention in the OR. Herman DeBoard, PhD, discusses how these technologies safeguard sterile fields, reduce SSIs, and help hospitals balance operational efficiency with patient safety.
Back to Basics: Hospital Restores Catheter-Associated UTI Rates to Prepandemic Baseline
June 16th 2025A 758-bed quaternary medical center slashed catheter-associated urinary tract infections (CAUTIs) by 45% over 2 years, proving that disciplined adherence to fundamental prevention steps, not expensive add-ons, can reverse the pandemic-era spike in device-related harm.
Beyond the Surface: Tackling the Sterilization Challenges of Flexible Endoscopes
May 26th 2025Flexible endoscopes revolutionized modern medicine—but their complex design poses persistent sterilization challenges. With mounting infection risks and emerging innovations, experts are rethinking how to clean and safeguard one of health care’s most indispensable tools.