Botulinum neurotoxin is probably best known to Americans as BOTOX, a cosmetic medicine, rather than as a cause of potentially dangerous foodborne illnesses. Lesser known is that Clostridium botulinum, the bacterium that causes the neurointoxication, produces one of the most potent toxins on earth and is classified as a potential bioterrorism threat.
A machine-learning algorithm has the capability to identify hospitalized patients at risk for severe sepsis and septic shock using data from electronic health records (EHRs), according to a study presented at the 2017 American Thoracic Society International Conference. Sepsis is an extreme systemic response to infection, which can be life-threatening in its advanced stages of severe sepsis and septic shock, if left untreated.
The influenza virus turns infected lung cells into factories that churn out thousands of copies of the virus to spread the infection. St. Jude Children’s Research Hospital scientists have reported a promising new approach that uses an investigational cancer drug to dial down viral production and dramatically increase survival of flu-infected mice. The findings appear today in the journal Cell Reports.
Cases of human infection with Powassan virus (POWV), which can cause fatal neuroinvasive disease and long-term neurological effects, appear to be increasing in the United States. POWV is transmitted by Ixodes tick species found in North America. A comprehensive review of this potential emerging public health threat, the most recent research on the virus and its tick vector, and the diagnosis, treatment, and prevention of POWV disease is published in Vector-Borne and Zoonotic Diseases.
Q: I have been using steam tape to place indicator on paper i.e., count sheets, and instrument bags inside of surgical trays before sterilization. I have been doing this for a number of years. My manager informs me that you cannot use steam tape to hold an indicator in place, be-cause "there is no way to validate that the tape is sterile after sterilization." Please clarify or give justification for this statement.
Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, modified an experimental malaria vaccine and showed that it completely protected four of eight monkeys that received it against challenge with the virulent Plasmodium falciparum malaria parasite. In three of the remaining four monkeys, the vaccine delayed when parasites first appeared in the blood by more than 25 days.
Researchers are exploring the use of the revolutionary gene-editing tool CRISPR-Cas9 to fight human disease and agricultural blight. But a study from Indiana University has found several challenges to the method's use in saving lives and crops. The research, reported in the journal Science Advances, combines advanced genetic and statistical analyses to show how certain genetic and behavioral qualities in disease-carrying insects, like mosquitoes, make these species resistant to genetic manipulation.
Directly observed therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in the United States, compared to self-administered therapy from 1993 to 2013, according to new research presented at the ATS 2017 International Conference.
In June 2012, a 60-year-old man with flu-like symptoms walked into a private hospital in Jeddah, Saudi Arabia. Two weeks later, he died from multiple organ failure, becoming the first victim of a mysterious virus that came to be known as Middle East Respiratory Syndrome or MERS. The World Health Organization (WHO) has identified MERS as an urgent threat with no vaccine or treatment in sight. This could change thanks to a new anti-viral tool, developed by University of Toronto researchers.
In a turnabout, a biochemical self-destruct trigger found in many other types of cells appears to guard the lives of brain cells during an infection with West Nile virus. UW Medicine scientists led research showing that this chemical pathway doesn't have to sacrifice brain cells to destroy the viruses and recruit the body's defenses against infection.
A new study led by Colorado State University researchers found that Aedes aegypti, the primary mosquito that carries Zika virus, might also transmit chikungunya and dengue viruses with one bite. The findings shed new light on what's known as a co-infection, which scientists said is not yet fully understood and may be fairly common in areas experiencing outbreaks.