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The worst of the global Zika virus outbreak may be over but many key questions remain, such as why the virus persists in certain tissues after the systemic infection has cleared; how does the immune system counteract the virus and protect against reinfection; what determines the likelihood of long-term complications? New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8+ T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease. The findings mapping the structural landmarks or epitopes recognized by CD8+ cells appear in the January 12, 2017, issue of Cell Host & Microbe and provide an important tool to track Zika-specific T cells in the context of different disease models.

The ticks that transmit Lyme disease to people die of dehydration when exposed to a combination of high temperature and lowered humidity, a new USGS-led study has found. In an earlier related study, the researchers found that southern black-legged ticks, unlike northern ones, usually stay hidden under a layer of leaves, where they are less likely to encounter people. The research group, whose findings were published Jan. 11 in the journal PLOS ONE, hypothesizes that southern ticks typically shelter under leaves to retain moisture, and that this behavior is a key reason why Lyme disease is very uncommon in the South.

In the future, it will be possible to carry out tests of new drugs on bacteria much more efficiently using microfluidic devices, since each of the hundreds and thousands of droplets moving through the microchannels can act as separate incubators. So far, however, there has been no quick or accurate method of assessing the oxygen conditions in individual microdroplets. This key obstacle has been overcome at the Institute of Physical Chemistry of the Polish Academy of Sciences.

Mumps emerged among highly vaccinated populations in the Netherlands, and this offered a unique opportunity to study mumps virus transmission. In particular the extent to which asymptomatic infections in vaccinated people contribute to ongoing mumps virus transmission is uncertain. Hahné, et al. (2017) say insight into this could help project the future burden of mumps in vaccinated populations. They therefore studied the relative infectiousness of symptomatic and asymptomatic cases.