Around the world, antibiotic use and resistance is increasing while the discovery of new antibiotics has nearly halted. In new research conducted by Michigan State University and published in the current issue of the journal mBio, this troubling trend is exacerbated by concentrated animal feeding operations. Results from the study show that in large swine farms where antibiotics are used continuously in feed for growth promotion and disease prevention, multidrug-resistant bacteria are likely the norm rather than the exception.
The research team, led by James Tiedje, the MSU distinguished professor of microbiology and molecular genetics and of plant, soil and microbial sciences, studied large-scale swine farms in China and one population of pigs in the U.S. They confirmed the presence of many partner genes -- resistance genes and mobile genetic elements found together. Simply put, when one gene increased or decreased in abundance, partner genes increased or decreased in nearly identical fashion.
"In the fight against the rise of antibiotic resistance, we need to understand that the use of one antibiotic or, in some cases, antibacterial disinfectants may increase the abundance of multidrug resistant bacteria," he said. "Tracking the source of antibiotic resistance is quite complicated because antibiotic use, which increases the occurrence of resistance, is widespread, and antibiotic resistance can spread between bacteria."
The Chinese farms are quite close to large cities. So controlling antibiotic resistance in pigs and farms is important to minimizing human risk. The complexity of finding the sources of antibiotic-resistant bacteria contributes to a global health concern, causing an estimated $20 billion in healthcare costs each year in the U.S.
"This is a global issue rather than one that's simply isolated in China; multidrug resistance is just a plane ride away," Tiedje added. "This is why our work in China is definitely as relevant as in the United States."
Some of these partner genes can make bacteria resistant to antibiotics that were not even fed to the animals. These partner genes were likely present in the same bacteria that were resistant to one of the antibiotics that was fed to the pigs. So when one antibiotic is used, resistance to many antibiotics can increase.
"At the Chinese farms, there were not only two partner genes, but 14 partner genes, all occurring together in farms that are thousands of miles apart," said Tim Johnson, lead author with MSU's Center for Microbial Ecology. "These genes confer resistance to up to six kinds of antibiotics, and some allow bacteria to reshuffle the order of their genes."
In Chinese soils that received manure-based fertilizer, the same resistance genes were found in manure and in high abundance. However, the kinds of bacteria present in soil were quite different. This indicates that on the Chinese farms, the potential for resistance gene transfer among environmental bacteria is likely, said Yongguan Zhu, co-author from the Chinese Academy of Science.
"Our results clearly show the diversity of resistance genes on swine farms and that many genes likely originated from the same source. We also showed the linkage of resistance genes to each other as well as genes that enable them to be clustered in one bacteria or shared among bacteria," Tiedje said. "These findings will help guide practice and policies for prudent agricultural antibiotic use and to minimize antibiotic resistance genes spread to pathogens."
Additional MSU researchers contributing to this study included Robert Stedtfeld, Qiong Wang, James Cole and Syed Hashsham.
Torey Looft, with the USDA's National Animal Disease Center, and Yong-Guan Zhu, of the Chinese Academy of Sciences' Institute of Urban Environment and Research Center for Eco-environmental Sciences, also contributed to this study.
This research was funded by the United States Department of Agriculture and Natural Science Foundation of China.
Source: Michigan State University
The Next Frontier in Infection Control: AI-Driven Operating Rooms
Published: July 15th 2025 | Updated: July 15th 2025Discover how AI-powered sensors, smart surveillance, and advanced analytics are revolutionizing infection prevention in the OR. Herman DeBoard, PhD, discusses how these technologies safeguard sterile fields, reduce SSIs, and help hospitals balance operational efficiency with patient safety.
Targeting Uncertainty: Why Pregnancy May Be the Best Time to Build Vaccine Confidence
July 15th 2025New national survey data reveal high uncertainty among pregnant individuals—especially first-time parents—about vaccinating their future children, underscoring the value of proactive engagement to strengthen infection prevention.
CDC Urges Vigilance: New Recommendations for Monitoring and Testing H5N1 Exposures
July 11th 2025With avian influenza A(H5N1) infections surfacing in both animals and humans, the CDC has issued updated guidance calling for aggressive monitoring and targeted testing to contain the virus and protect public health.
IP LifeLine: Layoffs and the Evolving Job Market Landscape for Infection Preventionists
July 11th 2025Infection preventionists, once hailed as indispensable during the pandemic, now face a sobering reality: budget pressures, hiring freezes, and layoffs are reshaping the field, leaving many IPs worried about their future and questioning their value within health care organizations.