The human species is dependent for its survival on the billions of microorganisms that inhabit multiple environmental niches within and on the human body. While microbes are commonly associated with diseases and infections, they are also vital in essential, beneficial roles such as digestion, where they help synthesize vitamins and ferment complex indigestible carbohydrates.
The overwhelming majority of microbial species (>99 percent) resist cultivation in the laboratory. However, recent advances in microbial genomics and sequencing technology have allowed researchers to study microbes in their natural environment. The identification and characterization of these microbial communities will undoubtedly establish links between these microorganisms and disease, their roles in the development of the immune system and their overall impact on human evolution.
Claire Fraser-Liggett, director of the Institute for Genome Sciences at the University of Maryland School of Medicine and a globally recognized microbial genomics scientist, is a lead researcher with the Human Microbiome Project (HMP), an international National Institutes of Health roadmap initiative to study the impact of microbes on human health and disease.
Fraser-Liggett’s research focuses on microbes’ roles in the development of the immune system and their overall impact on human health. Her HMP research has particular emphasis on the human gastrointestinal tract, since this environment is home to the largest number of microbial “partners.” One of the ultimate goals of the HMP is to better understand our microbiota, and, in the future, to be able to optimize the beneficial effects of microbiota for each individual.
“The human GI tract contains the densest concentration of bacteria in our bodies, and studying these GI microbes gives us insights into health and illness in the developed world and in developing countries,” said Fraser-Liggett.
Beyond the Surface: Rethinking Environmental Hygiene Validation at Exchange25
June 30th 2025Environmental hygiene is about more than just shiny surfaces. At Exchange25, infection prevention experts urged the field to look deeper, rethink blame, and validate cleaning efforts across the entire care environment, not just EVS tasks.
A Controversial Reboot: New Vaccine Panel Faces Scrutiny, Support, and Sharp Divides
June 26th 2025As the newly appointed Advisory Committee on Immunization Practices (ACIP) met for the first time under sweeping changes by HHS Secretary Robert F. Kennedy Jr, the national spotlight turned to the panel’s legitimacy, vaccine guidance, and whether science or ideology would steer public health policy in a polarized era.
Getting Down and Dirty With PPE: Presentations at HSPA by Jill Holdsworth and Katie Belski
June 26th 2025In the heart of the hospital, decontamination technicians tackle one of health care’s dirtiest—and most vital—jobs. At HSPA 2025, 6 packed workshops led by experts Jill Holdsworth and Katie Belski spotlighted the crucial, often-overlooked art of PPE removal. The message was clear: proper doffing saves lives, starting with your own.