Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al., "Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus" appears in the September 2009 issue of the American Journal of Pathology.
Highly pathogenic avian influenza, commonly known as bird flu, is a strain of the influenza virus that has adapted to infect birds. Although bird-specific flu strains rarely cross species, further adaption can lead to lethal infection in humans.
To determine which genetic changes may lead to host adaptation, Gülsah Gabriel (currently at the Heinrich-Pette-Institute for Experimental Virology and Immunology the University of Hamburg) and Hans-Dieter Klenk at the Institute of Virology at the Philipps University of Marburg examined two strains of avian influenza, an unadapted avian strain and an avian strain adapted to infect mice by mutations that increase the efficiency of the viral polymerase. They found that whereas the avian strain only infected the lungs, the mouse-adapted strain caused suppression of the immune system, which resulted in infection in multiple organs. In addition, while the avian strain caused only mild symptoms in mice, the mouse-adapted strain led to severe illness including pneumonia and infection of the brain, followed by death. The viral polymerase may therefore provide an important target in preventing systemic flu in humans.
Gabriel et al. suggest that "reduction of high virus loads by targeting the viral polymerase may play an important role in the treatment of human influenza with systemic virus spread." In future studies, Gabriel and colleagues will aim to develop drugs interfering with virus polymerase activity.
This work was supported by grants from the Deutsche Forschungsgemeinschaft, the European Commission and the BBSRC.
Reference: Gabriel G, Klingel K, Planz O, Bier K, Herwig A, Sauter M, Klenk H-D: Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus. Am J Pathol 2009 175:1178-1186.
The Next Frontier in Infection Control: AI-Driven Operating Rooms
Published: July 15th 2025 | Updated: July 15th 2025Discover how AI-powered sensors, smart surveillance, and advanced analytics are revolutionizing infection prevention in the OR. Herman DeBoard, PhD, discusses how these technologies safeguard sterile fields, reduce SSIs, and help hospitals balance operational efficiency with patient safety.
Targeting Uncertainty: Why Pregnancy May Be the Best Time to Build Vaccine Confidence
July 15th 2025New national survey data reveal high uncertainty among pregnant individuals—especially first-time parents—about vaccinating their future children, underscoring the value of proactive engagement to strengthen infection prevention.
CDC Urges Vigilance: New Recommendations for Monitoring and Testing H5N1 Exposures
July 11th 2025With avian influenza A(H5N1) infections surfacing in both animals and humans, the CDC has issued updated guidance calling for aggressive monitoring and targeted testing to contain the virus and protect public health.
IP LifeLine: Layoffs and the Evolving Job Market Landscape for Infection Preventionists
July 11th 2025Infection preventionists, once hailed as indispensable during the pandemic, now face a sobering reality: budget pressures, hiring freezes, and layoffs are reshaping the field, leaving many IPs worried about their future and questioning their value within health care organizations.