EMERYVILLE, Calif. -- Chiron Corporation today announced that it has received a license for its new meningococcal B vaccine for New Zealand, MeNZB. Chiron developed the vaccine, in close collaboration with the New Zealand Ministry of Health and the Norwegian Institute of Public Health, to protect against the specific
meningococcal B strain responsible for a 13-year epidemic in the country.
Prior to the New Zealand regulatory authorities issuing the license, no other
vaccine was available to protect against this strain of meningococcal B
disease.
"Approval from the New Zealand authorities is the final milestone before
roll-out of this important vaccine," said John Lambert, president of Chiron
Vaccines. "Vaccination represents the best chance of ending the meningococcal
B epidemic that has struck New Zealand for more than a decade, affecting in
excess of 5,000 people and leaving hundreds dead or permanently disabled.
"Through the hard work of the entire multinational team, we have
developed, tested, scaled-up, manufactured and achieved regulatory approval
for this New Zealand strain vaccine in just three years, a fraction of the
time usually required. This accomplishment builds on Chiron's leadership
position in the meningococcal field, established through the contribution of
our Menjugate vaccine to the meningococcal C eradication campaign in the
United Kingdom."
Since the signing of the initial 2001 agreement with the New Zealand
Ministry of Health, Chiron has supplied vaccine for clinical studies conducted
in collaboration with the Ministry of Health and the University of Auckland.
The study results, which demonstrate MeNZB's favorable safety and
immunogenicity profile, comprised part of the license application that was
recently approved by the New Zealand regulatory authority, Medsafe. In
parallel with the clinical program, Chiron scaled up production to industrial
levels. Subsequently, Chiron completed several large-scale manufacturing
runs, producing vaccine for the nationwide vaccination campaign to begin in
South Auckland in the coming days.
"Developing this vaccine in such a short time frame is a great
achievement, and we must congratulate the whole team for their hard work,"
said Annette King, New Zealand's minister of health. "With our country
bearing some of the developed world's highest rates of meningococcal disease,
ensuring that our children and young people receive this vaccine is currently
one of our most important public health priorities. I therefore welcome
Medsafe's rapid review and approval of MeNZB that allow us to begin a
nationwide immunization program and congratulate Chiron for their effort and
dedication to this project."
Meningococcal disease results from infection caused by the bacterium
Neisseria meningitidis, known as meningococcus. Meningococcal disease usually
affects the membranes around the brain and spinal cord or the bloodstream,
causing meningitis or septicemia, respectively. Meningococcal disease can
result in brain damage, blindness, deafness, limb amputations and death.
Infection may be fatal even if diagnosed early, making prevention essential.
Source: Chiron Corporation
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