Dog Trained to Sniff Out Clostridium difficile

Article

A new study published in BMJ conducted by investigators at two large hospitals in The Netherlands shows that a trained dog was able to detect Clostridium difficile with high estimated sensitivity and specificity, both in stool samples and in hospital patients infected with C. difficile.

The detection dog. Courtesy of BMJ

A new study published in BMJ conducted by investigators at two large hospitals in The Netherlands shows that a trained dog was able to detect Clostridium difficile with high estimated sensitivity and specificity, both in stool samples and in hospital patients infected with C. difficile.

Bomers, et al. (2012) conducted this proof of principle study using a case-control design.  A 2-year-old beagle was trained to identify the smell of C difficile and tested on 300 patients (30 with C difficile infection and 270 controls). According to the researchers, the dog was guided along the wards by its trainer, who was blinded to the participants infection status. Each detection round concerned 10 patients (one case and nine controls). The dog was trained to sit or lie down when C. difficile was detected.

Main outcome measures were sensitivity and specificity for detection of C difficile in stool samples and in patients. The dogs sensitivity and specificity for identifying C difficile in stool samples were both 100 percent (95 percent confidence interval 91 percent to 100 percent). During the detection rounds, the dog correctly identified 25 of the 30 cases (sensitivity 83 percent, 65 percent to 94 percent) and 265 of the 270 controls (specificity 98 percent, 95 percent to 99 percent).

Reference: Bomers MK, et al. Using a dogs superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study. British Medical Journal. December 2012; 345.

Related Videos
Rare Disease Month: An Infection Control Today® and Contagion® collaboration.
Lucy S. Witt, MD, investigates hospital bed's role in C difficile transmission, emphasizing room interactions and infection prevention
Chikungunya virus, 3D illustration. Emerging mosquito-borne RNA virus from Togaviridae family that can cause outbreaks of a debilitating arthritis-like disease   (Adobe Stock 126688070 by Dr Microbe)
Ambassador Deborah Birx, , speaks with Infection Control Today about masks in schools and the newest variant.
Woman lying in hospital bed (Adobe Stock, unknown)
Deborah Birx, MD
Centers for Disease Control and Prevention  (Adobe Stock, unknown)
CDC (Adobe Stock, unknown)
Inside Track with Infection Control Today
Related Content