HERENTALS, Belgium -- Kemin Pharma announces the identification of novel, carbohydrate-based molecules with highly effective and selective activity against human cytomegalovirus (CMV).
"In our initial in vitro screening, a new molecule, identified as KPE1015, was nearly as effective as the positive control, ganciclovir, the only antiviral treatment currently available against CMV. We were able to chemically modify and optimize this lead molecule, creating molecule KPE1116, which delivered improved in vitro activity, superior to ganciclovir, against both the Davis and AD-169 strains of CMV," says Dr. Benedikt Sas, general manager of Kemin Pharma.
These molecules are part of a new class of molecules being screened by Kemin Pharma that exhibit very promising activity, selectivity and toxicity profiles. Sas says, "Our research is focused on complete, novel molecules with three dimensional structures, several chiral centers and new modes of action. There are few pharmaceutical compounds with chiral centers, because most are flat molecules."
An effective treatment for CMV infections is especially significant for immunodeficient patients, including AIDS patients, patients receiving chemotherapy, organ transplant recipients and pregnant women. CMV infection can cause a number of symptoms including retinitis, viral pneumonia, colitis, hepatitis, encephalitis and mononucleosis.
"We are excited about this promising new molecule. The current available treatment for CMV has a number of undesirable side effects including reduction in white blood cells, kidney damage, nausea, vomiting, diarrhea and rash. Plus, studies and surveillance data are showing an ever-increasing level of CMV resistance to the treatment," Sas added.
Kemin Pharma was established in January 2001 as a wholly owned, independent subsidiary of Kemin Industries, Inc. Its mission is to develop new, unique, antimicrobial compounds effective against bacteria, viruses and fungi, as well as protozoa, which present a serious, unmet medical challenge throughout the world. Kemin Pharma's screening efforts are focused on compounds that are likely to have a higher success rate, a strategy that has been very successful for the company. In the first two years of its existence, Kemin Pharma researchers have isolated and are currently conducting preclinical trials on six compounds and are conducting Phase II clinical trials on another compound.
Source: Kemin Pharma
CDC Urges Vigilance: New Recommendations for Monitoring and Testing H5N1 Exposures
July 11th 2025With avian influenza A(H5N1) infections surfacing in both animals and humans, the CDC has issued updated guidance calling for aggressive monitoring and targeted testing to contain the virus and protect public health.
IP LifeLine: Layoffs and the Evolving Job Market Landscape for Infection Preventionists
July 11th 2025Infection preventionists, once hailed as indispensable during the pandemic, now face a sobering reality: budget pressures, hiring freezes, and layoffs are reshaping the field, leaving many IPs worried about their future and questioning their value within health care organizations.
A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings
July 9th 2025Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.