Joint replacements are among the most common elective surgeries, but around 1 in 100 patients suffer post-surgical infections, turning a routine procedure into an expensive and dangerous ordeal. Now, researchers at Stevens Institute of Technology have developed a "self-defensive surface" for these implants that release targeted micro-doses of antibiotics when bacteria approach, potentially sharply reducing infection rates.
The work, led by Matthew Libera, professor of materials science at Stevens, describes a method for coating implant surfaces with a lattice of microgels: flecks, each 100 times smaller than the diameter of a human hair, capable of absorbing certain antibiotics. The microgels' behavior is regulated by electrical charges, and the electrical activity of an approaching microbe causes them to leak antibiotics, preventing infections from taking root.
Microgels could be applied to a wide range of medical devices, including heart valves, tissue scaffolds, and even surgical sutures -- and with the market for hip implants alone forecasted to reach $9.1 billion by 2024, the technology has significant commercial potential. The United States Army, which helped fund the research, is also interested in deploying the technology in field hospitals, where infections currently occur in one-quarter of combat injuries.
"The potential impact for patients, and for the healthcare system, is tremendous," said Libera, who chairs the Stevens Conference on Bacteria-Material Interactions. Stevens doctorate candidate Jing Liang and biomedical engineering professor Hongjun Wang collaborated on the study, which appears in the journal Biomaterials.
Post-surgical infections are tough to beat because as microbes colonize surfaces, they form antibiotic-resistant layers called biofilms. Libera and his team disrupt this cycle by killing microbes before they can gain a foothold. "It only takes one bacterium to cause an infection," Libera said. "But if we can prevent infection until healing is complete, then the body can take over."
Unlike conventional treatments that flood the whole body with antibiotics, the Stevens team's approach is highly targeted, releasing tiny amounts of antibiotics to kill individual bacteria. That dramatically reduces the selective pressures that give rise to antibiotic-resistant "superbugs" -- a big improvement over both systemic treatments and local approaches such as blending antibiotics into bone cement, releasing orders of magnitude less antibiotic into the patient's system.
Other self-defensive surfaces currently in development rely on microbes' metabolic byproducts to trigger the release of antibiotics -- a less surefire approach than the Libera's method, which can kill even dormant bacteria. The team's microgels are also remarkably resilient, surviving ethanol sterilization and remaining stable for weeks at a time. Microgels also respond appropriately to human tissue, retaining their antibiotic load until it's needed and promoting healthy bone growth around treated surfaces.
To apply microgels to a medical device such as a knee joint, surgeons could dunk the device in a specially prepared bath for a few seconds; a brief dip in a second bath would then charge the microgels with antibiotics. In theory, surgeons could prepare devices on demand, immediately before implanting them, using antibiotics tailored to a patient's specific risk factors.
So far the approach has been tested in vitro, and the team is still working to fine-tune the microgels and enable them to deliver a wider range of antibiotics. Securing approval from the Food and Drug Administration (FDA) will be tricky, given the innovative nature of the technology, but Libera's team is working with industry partners to plan further demonstrations.
Source: Stevens Institute of Technology