NIH Scientists Discover Why Flu Virus Spreads in Cold Weather


A finding by a team of scientists at the National Institutes of Health may account for why the flu virus is more infectious in cold winter temperatures than during the warmer months. Briefly, at winter temperatures, the virus's outer covering, or envelope, hardens to a rubbery gel that shields the virus as it passes from person to person. With warmer weather, however, the protective gel melts to a liquid phase. But this liquid phase, apparently, isn't tough enough to protect the virus against the elements, and so the virus loses its ability to spread from person to person.

The findings were published on line March 2 in Nature Chemical Biology. The study was a collaboration between researchers at two NIH institutes, the National Institute of Child Health and Human Development, and the National Institute of Alcohol Abuse and Alcoholism.

"The study results open new avenues of research for thwarting winter flu outbreaks," said NICHD director Duane Alexander. "Now that we understand how the flu virus protects itself so that it can spread from person to person, we can work on ways to interfere with that protective mechanism."

Flu is caused by a group of viruses known as influenza viruses. These are usually spread from person to person through coughs and sneezes. Infection with flu virus can cause fever, sore throat, muscle aches, severe headache, coughing, weakness and general discomfort. The virus can cause mild to severe illness, and at times can lead to death.

In October 2007, researchers working with guinea pigs showed that animals sick with the flu were more likely to get other guinea pigs sick at colder temperatures than at warmer temperatures.

In the current study, the NIH researchers used a technique called magic angle spinning nuclear magnetic resonance to create detailed images of how the virus's outer membrane responded to variations in temperature. The virus's outer membrane is composed chiefly of molecules known as lipids, explained the study's senior author Joshua Zimmerberg, PhD, chief of NICHD's Laboratory of Cellular And Molecular Biophysics. This family of molecules does not mix with water, and includes oils, fats, waxes, and cholesterol.

Zimmerberg and his colleagues found that at temperatures slightly above freezing, the virus's lipid covering solidified into a gel. When temperatures reached about 60 degrees Fahrenheit, the covering began to thaw, and the covering turned to a soupy mix.

Cooler temperatures, apparently, cause the virus to form the rubbery outer covering that can withstand travel from person to person. Once in the respiratory tract, the warm temperature in the body causes the covering to melt to its liquid form, so that the virus can infect the cells of its new host.

"Like an M&M in your mouth, the protective covering melts when it enters the respiratory tract," Zimmerberg said. "It's only in this liquid phase that the virus is capable of entering a cell to infect it.

In spring and summer, however, the temperatures are too high to allow the viral membrane to enter its gel state. The individual flu viruses apparently dry out and weaken, and the flu season wanes.

The finding opens up new possibilities for future research, Zimmerberg said. Strategies to disrupt the virus and prevent it from spreading could involve seeking ways to disrupt the virus's lipid membrane.

In cold temperatures, the hard lipid shell can be resistant to certain detergents, so one strategy could involve testing for more effective detergents and hand-washing protocols to hinder the spread of the virus.

Similarly, Zimmerberg theorizes that in areas affected by a severe form of the flu, people might better protect themselves against getting sick by remaining indoors at warmer temperatures than usual.

Source: National Institutes of Health

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