Patients with an infection of the inner lining on the left side of the heart (endocarditis) who were switched from intravenous to oral antibiotic therapy had better long-term survival and fewer complications than similar patients who remained on conventional intravenous antibiotic therapy, according to research presented at the American College of Cardiology's 68th annual scientific session.
While initial six-month data had shown that partial treatment with oral antibiotics was similar in efficacy and safety to conventional intravenous therapy for left-sided infectious endocarditis, longer follow-up (median of 3.5 years) demonstrates this therapeutic approach is better for patients, said Henning Bundgaard, MD, PhD, DMSc, professor of cardiology at the Heart Center at the National University Hospital in Copenhagen, Denmark, and the study's lead author.
"In stabilized patients with left-sided infectious endocarditis, a switch from intravenous to oral antibiotic therapy showed superior efficacy and safety compared with continued intravenous treatment," he said. "These findings clearly support a change in the standard of care for this condition."
People with pre-existing heart valve disease, previous endocarditis, prosthetic heart valves or other implanted cardiac devices have an elevated risk for infectious endocarditis. The condition most often occurs on the left side of the heart in the mitral or aortic valve. Men are diagnosed with infectious endocarditis about twice as often as women.
The current study, known as POET, is the largest randomized trial of patients with infectious endocarditis, and was designed to test whether oral antibiotic therapy for left-sided infectious endocarditis was at least as effective and safe as intravenous treatment.
Clinical guidelines from several professional organizations currently recommend treating left-sided infectious endocarditis with intravenous antibiotics for up to six weeks. During the initial treatment phase, patients often need intensive care and close monitoring. Because intravenous antibiotics are logistically difficult to administer outside of a hospital, most patients remain in the hospital for the duration of their treatment.
Studies have suggested that intravenous treatment during long hospital stays may put patients at increased risk for complications. Oral antibiotics would allow patients to leave the hospital sooner and complete their treatment at home. Studies in other conditions have shown that patients with shorter hospital stays generally had better outcomes.
A total of 400 patients (average age 67 years; 77 percent male) with left-sided infectious endocarditis were enrolled in the study. Study participants had to be in stable condition and to have had a satisfactory response to at least 10 days of intravenous antibiotic treatment before randomization. They were then randomly assigned to either continue with intravenous antibiotics or switch to oral treatment for an average of 17 days after they were diagnosed. Intravenously-treated patients remained in the hospital until they completed antibiotic therapy. Patients who switched to oral treatment were discharged from the hospital a median of three days after making the switch.
The study's primary endpoint was a composite of death from any cause, unplanned cardiac surgery, embolic events (e.g., stroke) and relapse of infection with the same pathogen from the time of randomization until the end of follow-up.
After a median of 3.5 years of follow-up, 53 patients (26.4 percent) in the group receiving partial oral treatment had a primary-endpoint event, compared with 76 patients (38.2 percent) in the intravenously treated group, a statistically significant difference. Eighty-seven patients died; of these, 54 (27.1 percent) were treated intravenously and 33 (16.4 percent) were treated with oral medications, a significant difference. No significant differences in outcome were seen for relapse of infection, unplanned cardiac surgery or embolic events. The magnitude of the difference between the two groups is sufficient to conclude that oral treatment is superior to intravenous treatment, Bundgaard said.
Only patients with left-sided infectious endocarditis caused by certain bacterial species were enrolled in the trial, Bundgaard said, and the results may not apply to the approximately 25 percent of patients whose conditions are caused by other bacteria. In addition, although patients with antibiotic-resistant bacteria were not excluded from the trial, none were enrolled. Bundgaard and his colleagues plan to conduct additional analyses to compare quality of life and treatment costs in the groups receiving intravenous and partial oral treatment.
This study was funded by the Danish Heart Foundation and the Danish Capital Regions Research Foundation.
Source: American College of Cardiology
I Was There: An Infection Preventionist on the COVID-19 Pandemic
April 30th 2025Deep feelings run strong about the COVID-19 pandemic, and some beautiful art has come out of those emotions. Infection Control Today is proud to share this poem by Carmen Duke, MPH, CIC, in response to a recent article by Heather Stoltzfus, MPH, RN, CIC.
From the Derby to the Decontam Room: Leadership Lessons for Sterile Processing
April 27th 2025Elizabeth (Betty) Casey, MSN, RN, CNOR, CRCST, CHL, is the SVP of Operations and Chief Nursing Officer at Surgical Solutions in Overland, Kansas. This SPD leader reframes preparation, unpredictability, and teamwork by comparing surgical services to the Kentucky Derby to reenergize sterile processing professionals and inspire systemic change.
Show, Tell, Teach: Elevating EVS Training Through Cognitive Science and Performance Coaching
April 25th 2025Training EVS workers for hygiene excellence demands more than manuals—it requires active engagement, motor skills coaching, and teach-back techniques to reduce HAIs and improve patient outcomes.