Researchers Find New Pathway to Thwart Antibiotic Resistance


Researchers at University of Alabama at Birmingham (UAB) have new information on the structure of a key enzyme in bacteria that could lead to improved antibiotics and less antibiotic resistance. In findings published today online in two papers in the journal Nature, the research team describe the differences in an enzyme called RNA polymerase in bacterial cells as opposed to human cells. These differences provide potential new targets for drug design.

RNA polymerase is the key enzyme regulating the transfer of genetic information from DNA to RNA, said Dmitry Vassylyev, PhD, professor of biochemistry and molecular genetics and lead author of both papers. All living organisms use this enzyme to transmit the instructions stored in genes (DNA) to messenger RNA (mRNA), which in turn communicates those instructions to the cells.

Specifically, Vassylyevs team traced the similarities and differences between human RNA polymerase and bacteria RNA polymerase, painting a more complete picture of the structure of this essential enzyme.

Knowing how RNA polymerase differs in human and bacterial cells means antibiotics can be designed with a greater probability that they will interact with and kill bacteria, while leaving healthy human cells alone, Vassylyev said.

Vassylyev said that not only does this present a pathway for new antibiotics, it also should allow for existing drugs to be improved. Some antibiotics are very good at killing bacteria, for instance, but have a difficult time penetrating the cell membrane, rendering them fairly ineffective.

Vassylyevs detailed view of RNA polymerase provides a foundation for producing drugs that will efficiently enter cells, bind to the RNA polymerase and destroy bacteria without inhibiting the growth of human cells.

Vassylyev collaborated with Irina Artsimovitch of Ohio State University and Robert Laudick of the University of Wisconsin. The research was funded by the National Institute of General Medicine Sciences, one of the National Institutes of Health.

Source: UAB





Related Videos
Jill Holdsworth, MS, CIC, FAPIC, CRCST, NREMT, CHL
Jill Holdsworth, MS, CIC, FAPIC, CRCSR, NREMT, CHL, and Katie Belski, BSHCA, CRCST, CHL, CIS
Baby visiting a pediatric facility  (Adobe Stock 448959249 by
Antimicrobial Resistance (Adobe Stock unknown)
Anne Meneghetti, MD, speaking with Infection Control Today
Patient Safety: Infection Control Today's Trending Topic for March
Infection Control Today® (ICT®) talks with John Kimsey, vice president of processing optimization and customer success for Steris.
Picture at AORN’s International Surgical Conference & Expo 2024
Infection Control Today and Contagion are collaborating for Rare Disease Month.
Related Content