Smallpox Vaccine May Cause Harmless Skin Rashes

Article

ALEXANDRIA, Va. -- People who have never received a smallpox vaccination may develop any of a variety of benign skin rashes a few days after getting vaccinated for smallpox that should not be confused with a more serious complication of the vaccine, according to an article in the April 1, 2004 issue of Clinical Infectious Diseases.

Vaccinia is a virus used to immunize people against smallpox. The study examined 350 adult volunteers, 250 of whom were "vaccinia-naïve," or had never been vaccinated for smallpox before, and 100 of whom were "vaccinia-experienced," or had previously received a smallpox vaccination. Of the vaccinia-naïve, 3.6 percent developed some type of skin rash 6-19 days after being vaccinated. Symptoms usually included itching, redness and small bumps on the skin, and some patients also complained of headaches.

The five different types of rashes described in the article were all "self-limiting;" that is, they cleared up on their own after one to three weeks, and were not accompanied by fever or any other serious symptoms. The harmlessness of the vaccinia-associated skin rashes makes the findings important, according to Dr. Richard Greenberg, lead author of the study, which took place from July 2002 to February 2003.

"Physicians need to know that the skin reactions are benign and can be treated with medicines such as antihistamine," said Greenberg, of the University of Kentucky School of Medicine. "Doctors who realize that the rashes are not dangerous can offer reassurance to concerned patients and prescribe appropriate medications for symptom relief."

"A physician who is unaware of the possibility for a benign skin reaction might wrongly assume that a patient's rash was the development of one of the more dangerous vaccinial lesions. "The concern is that the physician would overreact," Greenberg said. "These skin reactions are rather dramatic, and if we're going to be vaccinating against smallpox, the physician should know that these are benign complications and not subject the patient to unnecessary worry."

Source: Infectious Diseases Society of America (IDSA)

Related Videos
Patient Safety: Infection Control Today's Trending Topic for March
Infection Control Today® (ICT®) talks with John Kimsey, vice president of processing optimization and customer success for Steris.
Picture at AORN’s International Surgical Conference & Expo 2024
Infection Control Today and Contagion are collaborating for Rare Disease Month.
Rare Disease Month: An Infection Control Today® and Contagion® collaboration.
Vaccine conspiracy theory vector illustration word cloud  (Adobe Stock 460719898 by Colored Lights)
Rare Disease Month: An Infection Control Today® and Contagion® collaboration.
Infection Control Today Topic of the Month: Mental Health
Infection Control Today's topic of the month: Mental Health
Related Content