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Flu season is on its way, and a new report in the Journal of Leukocyte Biology has identified an innovative strategy for battling this deadly illness. Scientists showed that a small protein called retrocyclin-101 (RC-101) could potentially improve the symptoms and mortality associated with the flu and possibly other types of infectious illness. As a potential drug candidate, RC-101 is unique in that it not only targets the influenza virus, but also the harmful inflammation it causes.
"Every year, thousands of people across the country die from the flu or its complications--despite widespread use of annual influenza vaccines," said Daniel J. Prantner, PhD, a research associate in the Department of Microbiology and Immunology at the University of Maryland School of Medicine (UM SOM). "In the future, we hope to see RC-101 approved for use in the clinic, where it can be another tool in the battle against this disease."
To make their discovery, Dr. Prantner and his colleagues used isolated mouse and human macrophages in vitro, and a mouse influenza infection model. Using the isolated macrophage model, the researchers found that RC-101 inhibited the production of inflammatory cytokines. In the animal model, the researchers infected two groups of mice with a lethal dose of influenza. They gave one of these groups RC-101 two days after infection for a total of five days, and gave the other group a placebo control. The mice that were treated with RC-101 exhibited less severe symptoms of the flu and decreased mortality compared to the control group.
"While viruses such as influenza cause a lot of damage themselves when people get infected, it is often the immune response that leads to severe tissue destruction trying to eradicate the infection," said John Wherry, PhD, deputy editor of the Journal of Leukocyte Biology. "These new findings using RC-101 may teach us how to efficiently allow the immune response clears a virus, while preventing the most damaging parts of the inflammatory response."
Reference: Daniel Prantner, Kari Ann Shirey, Wendy Lai, Wuyuan Lu, Alexander M. Cole, Stefanie N. Vogel, and Alfredo Garzino-Demo. The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. J Leukoc Biol, October 2017 102:1103-1113; doi:10.1189/jlb.2A1215-567RR