Varicella Vaccine Effective on Chicken Pox; Impact on Herpes Zoster Unclear

Article

NEW HAVEN, Conn. -- The varicella vaccine is almost 90 percent effective against chickenpox, but its impact on herpes zoster (shingles) is unknown and needs wider surveillance, Yale School of Medicine researchers write in the New England Journal of Medicine (NEJM) perspective section.

 

The varicella virus causes both chickenpox and herpes zoster, which occurs when a latent virus in the brain becomes reactivated and causes a painful rash on the skin, leading to severe pain and burning along nerves. Zoster affects people with compromised immune systems, such as the elderly. Since 1995, when the varicella vaccine was first introduced in the United States, it has greatly reduced the number of chickenpox cases and deaths from varicella. The vaccine may also have a key role in preventing zoster.

 

Even though it has been shown that varicella vaccine has had a major impact on the epidemiology of chickenpox in the United States, we do not know what impact, if any, the widespread use of varicella vaccine will have on the epidemiology of herpes zoster or shinglesits incidence, age distribution and severity, said Marietta Vazquez, MD, an author on the article and assistant professor in the department of pediatrics at Yale School of Medicine.

 

Referring to a study in the same issue, Vazquez and co-author Eugene D. Shapiro, MD, professor in the Departments of Pediatrics and Epidemiology and Public Health at Yale, note that the study shows a significant decline of 66 percent in mortality due to varicella.

 

These findings are relevant because they emphasize the importance of continuing the varicella vaccination program, said Vazquez. It is possible that varicella vaccine may be useful in helping prevent zoster if it is administered to elderly persons who have had chickenpox. The long-term effects of universal vaccination on both chickenpox and zoster need to be assessed so that the vaccine policy can be modified, if necessary.


Source: Yale University

 

Recent Videos
Mark Wiencek, PhD
Rebecca Crapanzano-Sigafoos, DrPH, CIC, AL-CIP, FAPIC
The CDC’s updated hospital respiratory reporting requirement has added new layers of responsibility for infection preventionists. Karen Jones, MPH, RN, CIC, FAPIC, clinical program manager at Wolters Kluwer, breaks down what it means and how IPs can adapt.
Studying for the CIC using a digital tablet and computer (Adobe Stock 335828989 by NIKCOA)
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Cheron Rojo, BS, FCS, CHL,  CER, CFER, CRCST
Matthias Tschoerner, Dr Sc
Standardizing Cleaning and Disinfection
Concept images of Far-UVC  (Adobe Stock 316993517 by hopenv)
Related Content