A Warming Climate Puts Europe at Risk for Seasonal Outbreaks of Dengue Fever

Map on the left shows areas with current dengue epidemic potential (from Aedes mosquitos). Map on top right shows future dengue epidemic potential during 2090s, under high emission scenario. Courtesy of Jing Liu-Helmersson
 

Increasing temperatures will enlarge Europe's seasonal window for the potential spread of mosquito-borne viral disease, expanding the geographic areas at risk for a dengue epidemic to include much of Europe. The findings by researchers at Umeå University in Sweden are published in the journal EBioMedicine.

Researchers at Umeå University's Unit for Global Health have calculated the risk for dengue outbreaks in Europe based on a set of different climate change predictions. Climate change-related temperature variations and overall warmer mean temperatures both have profound growth impacts on the ability of vectors - Aedes aegypti and Aedes albopicturs - to transmit dengue. The Aedes mosquitos, especially Aedes aegypti, are associated with most major dengue epidemics.

"The geographic expansion of dengue viruses and Aedes mosquitos as the carrying vectors is a major global health concern," says Jing Liu-Helmersson, researcher at the Department of Public Health and Clinical Medicine and main author of the article. "In the midst of warming temperatures on the European continent and a number of complex factors such as increased travel and trade, Europe now finds itself at an elevated risk of mosquito-borne epidemics such as dengue fever.

Earlier studies have shown that warming temperatures may increase the geographic spread of tropical and subtropical mosquito-borne viral diseases into temperate areas, such as Europe. The study published in EBioMedicine is the first to look at how increasing mean temperatures and its daily variation correspond with increases in vectorial capacity, i.e. the ability for a mosquito to transmit the disease between humans. Vectorial capacity depends on a number of parameters. In general, warmer temperatures increase virus reproduction and transmission, and the rate in which the female mosquitos bite. As a result, a warmer overall climate extends the seasonal window of opportunity for mosquitos to transmit dengue fever.

In determining the dengue epidemic risk for Europe, the Umeå University researchers studied the effects of temperature on vectorial capacity of Aedes mosquitos. Using historic and present climate data and vector surveillance data as well as various climate change scenarios as basis, the researchers determined dengue epidemic risks in Europe based on modest to severe warming projections.

The study shows that: 
•Current vectorial capacity indicates that dengue epidemics are possible in summer in areas of Southern Europe where Aedes mosquitos are present.
•Future climate change will intensify vectorial capacity and shift the risk areas northward while prolonging the seasonal window.
•By the end of the century, seasonal dengue outbreaks could emerge in much of Europe where Aedes mosquitos are present.

The Umeå University researchers argue that Aedes mosquitos are likely to become a fixture in Europe, based on several factors. Historically, Aedes mosquitos were present in many European countries during the first half of the 1900s. The main dengue vector - Aedes aegypti - has recently been documented in Russia and Georgia. And current surveillance indicate that the secondary dengue vector, Aedes albopictus, are present in much of Southern Europe and as far north as the Netherlands.

"The 2012-2013 dengue outbreak in Madeira was a wakeup call for Europe to act," says Liu-Helmersson. "More effective vector control will certainly be crucial to reduce the risk of dengue in Europe. But this is not as easy as it sounds. In Singapore, for example, is proving difficult to control Aedes mosquitos even with readily available resources. More importantly, however, our findings illustrate that mitigating greenhouse gas emissions to curb global warming will be just as crucial."

Source: Umea University