In a recent study published in the Journal of the American Medical Association (JAMA)1, Noto et al. found that in a “single-center, multi-ICU, cluster randomized, crossover study, once daily bathing with chlorhexidine did not reduce the rate of the composite primary outcome of infections including central-line associated bloodstream infections (CLABSI), catheter-associated urinary tract infections (CAUTI), possible or probable ventilator-associated pneumonia (VAP), or infection with C difficile.” The authors further concluded that these findings do not support daily bathing of critically ill patients with chlorhexidine.