The 4 out of 10 women who use antibiotics during pregnancy can breathe easy, as a comprehensive new study shows that the two most often prescribed drugs have no adverse outcome on the child’s physical development. The researchers, led by Anick Bérard of the University of Montreal and its affiliated CHU Sainte-Justine children’s hospital, and Hedvig Nordeng of the University of Oslo, looked at macrolides, a type of antibiotics.
“With penicillin, macrolides are amongst the most used medications in the general population and in pregnancy. However, debate remained on whether it is the infections or in fact the macrolides used to treat them that put women and their unborn child at greater risk of adverse pregnancy outcomes, including birth defects,” Bérard explains. “We therefore aimed to estimate the risk of major congenital malformations after foetal exposure to the two most commonly used macrolides, and failed to find any.”
The researchers referred to data held in the Quebec Pregnancy Cohort. Containing detailed medical information on hundreds of thousands of pregnancies, in addition to the outcomes for mother and newborn alike, it’s one of the world’s largest cohort of its type. Information on the mother’s use of pharmaceuticals – azithromycin and clarithromycin – was retrieved from Quebec’s public pharmaceutical insurance program and was compared to the use of penicillin, a well tolerated antibiotic.
“135,839 pregnancies met the criteria for inclusion in our study. Of these, 1.7 percent involved exposure to the macrolides during the first trimester, while 9.8% of pregnancies resulted in the child having a major congenital malformation. After statistical analysis, we found no meaningful association between the groups compared to penicillin use,” Bérard and Nordeng say.
The lack of previous clarity regarding the safety of these drugs may be due to overlooked confounding factors: for example, azithromycin is typically used to
treat chlamydia infections, infections that are associated with birth defects. Nonetheless, the researchers underscore that wider studies will need to be undertaken in order to confirm the safety of less-often prescribed antibiotics.
Anick Bérard, Odile Sheehy, Jin-Ping Zhao and Hedvig Nordeng published “Use of macrolides during pregnancy and the risk of birth defects: a population-based study” in Pharmacoepidemiology and Drug Safety on Oct. 30, 2015.
This study was funded by the Fonds de recherche du Québec – Santé (FRQS) and the Réseau Québécois de Recherche sur l’Usage des Médicaments (RQRUM). Anick Bérard is the recipient of a research chair on Medications and Pregnancy from the FRQS. Jin-Ping Zhao is a recipient of Quebec-China Competition Matching Funds Post-doctoral Fellowships.
Source: University of Montreal
A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings
July 9th 2025Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.
Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers
July 4th 2025Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.
How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels
July 3rd 2025Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.